Xia Ling-Zi, Yin Zhi-Hua, Ren Yang-Wu, Shen Li, Wu Wei, Li Xue-Lian, Guan Peng, Zhou Bao-Sen
China Medical University, Department of Epidemiology, School of Public Health, Shenyang, Peoples R China ; University of Liaoning Province, Key Laboratory of Cancer Etiology & Intervent, Shenyang, Peoples R China.
Springerplus. 2015 Apr 15;4:179. doi: 10.1186/s40064-015-0941-7. eCollection 2015.
LAPTM4B is a newly cloned gene that shows an active role in many solid tumors progression in substantial researches, mainly through the autophage function. Accumulated studies have been conducted to determine the association of LAPTM4B polymorphism with cancer risk. While the results are inconsistent, we conducted the meta-analysis to determine the strength of the relationship. Results showed that allele2 carriers exhibited a significantly increased risk of cancer development with comparison to allele1 homozygote (for *1/2, OR = 1.55, 95% CI 1.367-1.758; for *2/2, OR = 2.093, 95%CI 1.666-2.629; for 1/2 + 2/2, OR = 1.806, 95%CI 1.527-2.137). We also observed a significant association between 2/2 homozygote and cancer risk with comparison to allele1 containing genotypes (OR = 1.714, 95%CI 1.408-2.088). Allele2 is a risk factor for cancer risk (OR = 1.487, 95%CI 1.339-1.651). Stratified analysis by tumor type exhibits the significant association of this genetic variants with various cancers. In conclusion, LAPTM4B polymorphism is associated with cancer risk and allele2 is a risk factor.
LAPTM4B是一个新克隆的基因，大量研究表明其在许多实体瘤进展中发挥积极作用，主要通过自噬功能。已经开展了大量研究来确定LAPTM4B基因多态性与癌症风险的关联。尽管结果不一致，但我们进行了荟萃分析以确定两者关系的强度。结果显示，与等位基因1纯合子相比，等位基因2携带者患癌风险显著增加（对于1/2，OR = 1.55，95%CI 1.367 - 1.758；对于2/2，OR = 2.093，95%CI 1.666 - 2.629；对于1/2 + 2/2，OR = 1.806，95%CI 1.527 - 2.137）。与含等位基因1的基因型相比，我们还观察到2/2纯合子与癌症风险之间存在显著关联（OR = 1.714，95%CI 1.408 - 2.088）。等位基因2是癌症风险的一个危险因素（OR = 1.487，95%CI 1.339 - 1.651）。按肿瘤类型进行的分层分析显示该基因变异与多种癌症存在显著关联。总之，LAPTM4B基因多态性与癌症风险相关，等位基因2是一个危险因素。
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