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1
One protein, at least three structures, and many functions.一种蛋白质，至少三种结构，多种功能。
Structure. 2013 Jan 8;21(1):6-8. doi: 10.1016/j.str.2012.12.003.
2
Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection.在乙肝病毒感染中血清转化为抗-HBe和抗-HBs期间，异质性乙肝核心抗原和e抗原特异性CD4+ T细胞群体的激活。
J Virol. 1995 Jun;69(6):3358-68. doi: 10.1128/JVI.69.6.3358-3368.1995.
3
The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype.乙肝病毒核心抗原和e抗原可引发不同的Th细胞亚群：抗原结构能够影响Th细胞表型。
J Virol. 1997 Mar;71(3):2192-201. doi: 10.1128/JVI.71.3.2192-2201.1997.
4
Hepatitis B virus core and e antigen: immune recognition and use as a vaccine carrier moiety.乙肝病毒核心抗原与e抗原：免疫识别及作为疫苗载体部分的应用
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Localization of hepatitis B surface and core antigens in human hepatocellular carcinoma by immunoperoxidase methods. Replication of complete virions of carcinoma cells.应用免疫过氧化物酶法对人肝细胞癌中乙型肝炎表面抗原和核心抗原进行定位。癌细胞中完整病毒粒子的复制。
Cancer. 1985 Jul 15;56(2):321-7. doi: 10.1002/1097-0142(19850715)56:2<321::aid-cncr2820560220>3.0.co;2-d.
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DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes.用编码乙型肝炎病毒核心蛋白细胞内形式（HBcAg）或分泌形式（HBeAg）的质粒进行DNA疫苗接种，可引发T细胞对两个重叠的Kb和Kd限制性表位的反应。
Int Immunol. 1997 Aug;9(8):1203-12. doi: 10.1093/intimm/9.8.1203.
7
Comparative immunogenicity of hepatitis B virus core and E antigens.乙型肝炎病毒核心抗原与E抗原的免疫原性比较
J Immunol. 1988 Nov 15;141(10):3617-24.
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Biologic and prognostic significance of hepatocyte hepatitis B core antigen expressions in the natural course of chronic hepatitis B virus infection.慢性乙型肝炎病毒感染自然病程中肝细胞乙肝核心抗原表达的生物学及预后意义
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Association of hepatitis Be antigen (HBeAg) with the core of the hepatitis B virus (HBcAg).
Liver. 1985 Feb;5(1):48-53. doi: 10.1111/j.1600-0676.1985.tb00015.x.
10
Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma.伴有和不伴有肝细胞癌的患者体内乙肝病毒抗原的肝内分布情况。
World J Gastroenterol. 2016 Mar 28;22(12):3404-11. doi: 10.3748/wjg.v22.i12.3404.

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The regenerating protein 3A: a crucial molecular with dual roles in cancer.再生蛋白 3A：在癌症中具有双重作用的关键分子。
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Production of the HBc Protein from Different HBV Genotypes in . Use of Reassociated HBc VLPs for Packaging of ss- and dsRNA.不同乙肝病毒基因型在……中产生核心蛋白。使用重配的核心蛋白病毒样颗粒包装单链和双链RNA。
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Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.乙型肝炎病毒核心和 e 抗原免疫复合物的结构提示多点抑制。
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Monitoring Assembly of Virus Capsids with Nanofluidic Devices.利用纳米流体装置监测病毒衣壳的组装
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The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription.乙型肝炎病毒衣壳蛋白之间的界面影响自我组装、前基因组RNA包装和逆转录。
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The hepatitis B virus core protein intradimer interface modulates capsid assembly and stability.乙肝病毒核心蛋白二聚体内界面调节衣壳组装与稳定性。
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Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry.通过氢氘交换质谱法评估乙型肝炎病毒核心抗原和e抗原构象灵活性的差异。
Protein Sci. 2014 Jul;23(7):884-96. doi: 10.1002/pro.2470. Epub 2014 Apr 17.

本文引用的文献

1
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.乙型肝炎病毒通过衣壳蛋白的交替二聚化实现抗原转换。
Structure. 2013 Jan 8;21(1):133-142. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec 6.
2
Role of the propeptide in controlling conformation and assembly state of hepatitis B virus e-antigen.前肽在控制乙型肝炎病毒 e 抗原构象和组装状态中的作用。
J Mol Biol. 2011 Jun 3;409(2):202-13. doi: 10.1016/j.jmb.2011.03.049. Epub 2011 Apr 2.
3
Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly.乙型肝炎病毒核心蛋白构象变化与变构在病毒组装中的作用一致。
J Virol. 2010 Feb;84(3):1607-15. doi: 10.1128/JVI.02033-09. Epub 2009 Nov 25.
4
A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly.突变乙型肝炎病毒核心蛋白模拟二十面体衣壳自组装抑制剂。
Biochemistry. 2009 Mar 3;48(8):1736-42. doi: 10.1021/bi801814y.
5
Immune tolerance split between hepatitis B virus precore and core proteins.乙肝病毒前核心蛋白和核心蛋白之间的免疫耐受分裂
J Virol. 2005 Mar;79(5):3016-27. doi: 10.1128/JVI.79.5.3016-3027.2005.
6
Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L.自然发生的F97L突变增强了乙肝病毒衣壳组装。
J Virol. 2004 Sep;78(17):9538-43. doi: 10.1128/JVI.78.17.9538-9543.2004.
7
Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein.衣壳蛋白中两个独立的自然发生突变（P5T和L60V）导致人乙型肝炎病毒颗粒的低水平分泌。
J Virol. 2000 Oct;74(19):9099-105. doi: 10.1128/jvi.74.19.9099-9105.2000.
8
The crystal structure of the human hepatitis B virus capsid.人类乙型肝炎病毒衣壳的晶体结构。
Mol Cell. 1999 Jun;3(6):771-80. doi: 10.1016/s1097-2765(01)80009-5.
9
The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen.人乙肝病毒核心抗原第97位密码子高频自然发生错义突变导致未成熟分泌表型的机制
J Virol. 1999 Jul;73(7):5731-40. doi: 10.1128/JVI.73.7.5731-5740.1999.

一种蛋白质，至少三种结构，多种功能。

One protein, at least three structures, and many functions.

机构信息

Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47401, USA.

Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47401, USA.

出版信息

Structure. 2013 Jan 8;21(1):6-8. doi: 10.1016/j.str.2012.12.003.

DOI:10.1016/j.str.2012.12.003
PMID:23312031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3545281/
Abstract

Hepatitis B virus core gene products can adopt different conformations to perform their functional roles. In this issue of Structure, DiMattia and colleagues show the crystal structure of immuno-modulating HBeAg and thereby reveal the similarities and differences between it and HBcAg, the variant found in virions.

摘要

乙型肝炎病毒核心基因产物可以采用不同的构象来发挥其功能作用。在本期的《结构》杂志中，DiMattia 及其同事展示了免疫调节 HBeAg 的晶体结构，从而揭示了它与在病毒粒子中发现的 HBcAg 变体之间的相似之处和不同之处。