Levin E D, Lee C, Rose J E, Reyes A, Ellison G, Jarvik M, Gritz E
Nicotine Research Laboratory, Veterans Administration Medical Center, Durham, North Carolina 27705.
Behav Neural Biol. 1990 Mar;53(2):269-76. doi: 10.1016/0163-1047(90)90509-5.
Rats were tested for choice accuracy in an eight-arm radial maze during and after chronic administration of nicotine via subcutaneously implanted glass and Silastic capsules. Nicotine administration significantly improved choice accuracy relative to controls. The effect gradually became apparent over the first 2 weeks of exposure and persisted through the third week. Surprisingly, the significant facilitation of the nicotine-treated rats relative to controls continued for 2 weeks after the end of nicotine administration. No effects of nicotine were seen on choice latency or the strategy to make adjacent arm entries.
在通过皮下植入玻璃和硅橡胶胶囊长期给予尼古丁期间及之后，对大鼠在八臂放射状迷宫中的选择准确性进行了测试。与对照组相比，给予尼古丁显著提高了选择准确性。这种效果在暴露的前两周逐渐显现，并持续到第三周。令人惊讶的是，在停止给予尼古丁后，尼古丁处理组大鼠相对于对照组的显著促进作用持续了2周。未观察到尼古丁对选择潜伏期或进入相邻臂的策略有影响。
