PARP1 在热休克中的双重作用：转录激活因子和基因表达的转录后抑制剂。
Dual roles for PARP1 during heat shock: transcriptional activator and posttranscriptional inhibitor of gene expression.
机构信息
Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Mol Cell. 2013 Jan 10;49(1):1-3. doi: 10.1016/j.molcel.2012.12.017.
Abstract
In this issue of , Di Giammartino et al. (2012) identify a new function for PARP1 in the post-transcriptional regulation of mRNAs via ADP-ribosylation of poly(A) polymerase, a mRNA 3′ processing enzyme.
摘要
本期《 》中，Di Giammartino 等人（2012 年）发现 PARP1 通过多聚（A）聚合酶的 ADP-核糖基化作用在 mRNA 的转录后调控中发挥了新的功能，多聚（A）聚合酶是一种 mRNA 3'加工酶。
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