Institute of Stomatology, Nanjing Medical University, Department of Orthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.
Peptides. 2013 Apr;42:48-54. doi: 10.1016/j.peptides.2013.01.001. Epub 2013 Jan 8.
Obstructive sleep apnea (OSA) is a complicated disease with an unrecognized mechanism. Obesity, sex, age, and smoking have been found to be independent correlates of OSA. Orexin (also named hypocretin) mainly secreted by lateral hypothalamus neurons has a wide array of biological functions like regulating sleep, energy levels and breathing. Several clinical studies found ties between orexin and OSA. Because of the close correlation between orexin and obesity, sex, age and smoking (which are the key risk factors for OSA patients), we hypothesize that orexin may play a key role in the pathogenesis of OSA.
阻塞性睡眠呼吸暂停（OSA）是一种发病机制尚不明确的复杂疾病。肥胖、性别、年龄和吸烟已被发现是 OSA 的独立相关因素。食欲素（也称为下丘脑泌素）主要由下丘脑外侧神经元分泌，具有调节睡眠、能量水平和呼吸等广泛的生物学功能。几项临床研究发现食欲素与 OSA 之间存在关联。由于食欲素与肥胖、性别、年龄和吸烟（OSA 患者的关键危险因素）密切相关，我们假设食欲素可能在 OSA 的发病机制中起关键作用。
