Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Trends Cardiovasc Med. 2013 Apr;23(3):66-70. doi: 10.1016/j.tcm.2012.09.002. Epub 2013 Jan 10.
Stem cell therapies promise to regenerate the infarcted heart through the replacement of dead cardiac cells and stimulation of neovascularization. New research from our laboratory shows the transplantation of stem cells from human veins helps heart healing after an acute ischemic insult. Using a mouse model, we demonstrated that pericytes expanded from redundant human leg veins relocate around the vessels of the peri-infarct zone and release factors that promote reparative angiogenesis and cardiomyocyte survival and inhibit interstitial fibrosis. We plan to perform a first-in-man clinical trial with human pericytes in patients with refractory myocardial ischemia in the next 5 years.
干细胞疗法有望通过替换死亡的心肌细胞和刺激血管新生来使梗死的心脏再生。我们实验室的新研究表明，移植来自人体静脉的干细胞有助于急性缺血损伤后的心脏愈合。我们使用小鼠模型证明，从多余的人腿静脉中扩增的周细胞会重新定位到梗塞周围区域的血管周围，并释放促进修复性血管生成和心肌细胞存活以及抑制间质纤维化的因子。我们计划在未来 5 年内，在难治性心肌缺血患者中进行人类周细胞的首次人体临床试验。
