Hinriksdóttir Gunnhildur, Arngrímsson Sigurbjörn Á, Misic Mark M, Evans Ellen M
Center for Sport and Health Sciences, University of Iceland, Lindarbraut 4, 840 Laugarvatn, Iceland.
Center for Sport and Health Sciences, University of Iceland, Lindarbraut 4, 840 Laugarvatn, Iceland.
Maturitas. 2013 Mar;74(3):264-9. doi: 10.1016/j.maturitas.2012.12.009. Epub 2013 Jan 10.
To investigate the association between lean soft tissue (LST) and fat mass (FM) on bone health variables in women across the lifespan, while taking into account the influence of objectively measured habitual physical activity (PA).
A total of 104 women, 37 young (23.3 ± 2.6 years), 28 middle-age (49.2 ± 5.4 years), and 39 old (68.3 ± 6.4 years) participated in this cross-sectional study. All underwent a DXA scan and wore a pedometer for 7 days.
Bone mineral content (BMC) and BMD of the whole body (WB), lumbar spine (LS) and proximal femur (PF), and body composition (FM and LST) were assessed with DXA and PA (steps/day) was assessed from 7 day pedometer counts.
LST was significantly and positively associated with PF and LS BMD (r = 0.34; 0.67, p < 0.05), and WB, PF and LS BMC (r range = 0.41-0.59, p < 0.05) in all age groups and WB BMD in the middle-age group (r = 0.72, p < 0.05) independent of PA, FM, and hormonal status. FM was not positively associated with any bone variable in any age group when adjusted for PA, LST, and hormonal status. PA was significantly associated with WB BMD in the middle-age group (r = 0.60, p < 0.05), independent of LST, FM, and hormonal status.
LST contributes more to bone health in women across the lifespan than FM, independent of PA and hormonal status.
研究一生中不同阶段女性的瘦软组织（LST）和脂肪量（FM）与骨骼健康变量之间的关联，同时考虑客观测量的习惯性身体活动（PA）的影响。
共有104名女性参与了这项横断面研究，其中37名年轻女性（23.3±2.6岁），28名中年女性（49.2±5.4岁），39名老年女性（68.3±6.4岁）。所有参与者均接受了双能X线吸收法（DXA）扫描，并佩戴计步器7天。
采用DXA评估全身（WB）、腰椎（LS）和股骨近端（PF）的骨矿物质含量（BMC）和骨密度（BMD），并通过7天的计步器计数评估身体成分（FM和LST）以及PA（每天步数）。
在所有年龄组中，LST与PF和LS的BMD显著正相关（r = 0.34；0.67，p < 0.05），与WB、PF和LS的BMC显著正相关（r范围 = 0.41 - 0.59，p < 0.05），在中年组中与WB的BMD也显著正相关（r = 0.72，p < 0.05），且不受PA、FM和激素状态的影响。在调整了PA、LST和激素状态后，FM在任何年龄组中均未与任何骨骼变量呈正相关。在中年组中，PA与WB的BMD显著相关（r = 0.60，p < 0.05），且不受LST、FM和激素状态的影响。
在一生中不同阶段的女性中，独立于PA和激素状态，LST对骨骼健康的贡献比FM更大。
