University of Minnesota Medical School, Duluth, MN 55812, USA.
Biol Psychol. 2013 Apr;93(1):9-16. doi: 10.1016/j.biopsycho.2012.12.009. Epub 2013 Jan 8.
We examined whether social drinkers whose drinking behavior poses a risk for harmful consequences exhibit altered psychobiological responses to stress following moderate alcohol intake. At risk (n=17) and low risk drinkers (n=27), as identified by the Alcohol Use Disorders Identification Test, completed two laboratory stress sessions, one in which they consumed a drink with alcohol and one without alcohol. Subjective and physiological measures were obtained throughout the study. Reported stimulation following alcohol consumption and sedation post-stress on alcohol day were greater than the no alcohol day in at risk drinkers (ps<.05). Low risk drinkers exhibited stress dampening effects on cortisol levels (p<.05). This was not the case among the high risk drinkers. These results indicate that acute alcohol intake may be associated with enhanced subjective and altered hormonal responses to stress in individuals who are at risk for becoming problem drinkers.
我们研究了那些饮酒行为可能导致不良后果的社交饮酒者，在适度饮酒后，其应激时的心理生物学反应是否会发生变化。根据酒精使用障碍识别测试（Alcohol Use Disorders Identification Test），有风险（n=17）和低风险（n=27）的饮酒者完成了两次实验室应激试验，一次是饮酒，一次是不饮酒。在整个研究过程中，都获得了主观和生理测量数据。与无酒精日相比，在风险饮酒者中，饮酒后和应激后（酒精日）的兴奋感（reported stimulation）和镇静感（sedation）更高（p<.05）。低风险饮酒者的皮质醇水平呈现应激抑制效应（stress dampening effects）（p<.05）。但高风险饮酒者则并非如此。这些结果表明，在可能成为问题饮酒者的个体中，急性饮酒可能与应激时的主观增强和激素反应改变有关。
