Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1025 Budapest, Pusztaszeri út 59-67, Hungary.
J Pharm Biomed Anal. 2013 Mar 25;76:145-51. doi: 10.1016/j.jpba.2012.12.017. Epub 2012 Dec 22.
This paper reports the first application of surface enhanced Raman chemical imaging on pharmaceutical tablets containing the active ingredient (API) in very low concentrations. Taking advantage of the extremely intensive Raman signals in the presence of silver colloids, image aquisition time was radically decreased. Moreover, the investigation of drug distribution below the detection limit of regular micro-Raman spectrometry was made feasible. The characteristics of different manufacturing technologies could be revealed at very low API concentrations by using chemometric methods for processing and evaluating the large number of varying spectra provided with this imaging method.
本文报道了表面增强拉曼化学成像技术在含有极低浓度活性成分（API）的药片上的首次应用。利用银胶体存在时极其强烈的拉曼信号，大大缩短了图像采集时间。此外，还使得在常规微拉曼光谱检测限以下探测药物分布成为可能。通过使用化学计量学方法处理和评估这种成像方法提供的大量变化光谱，可以在非常低的 API 浓度下揭示不同制造技术的特点。
