电压门控性钾通道病：临床表型谱不断扩大
Voltage-gated potassium channelopathy: an expanding spectrum of clinical phenotypes.
作者信息
Shribman Sam, Patani Rickie, Deeb Jacquie, Chaudhuri Abhijit
机构信息
Department of Neurology, Queen's Hospital, Essex Centre for Neurological Sciences, London, UK.
出版信息
BMJ Case Rep. 2013 Jan 10;2013:bcr2012007742. doi: 10.1136/bcr-2012-007742.
Abstract
Autoimmune voltage-gated potassium channelopathies represent a wide and expanding spectrum of neurological conditions. We present a case demonstrating the phenotypic heterogeneity of antivoltage-gated potassium channels (VGKC)-associated disorders. Such cases may easily be dismissed as functional disorders at first presentation. We propose that there must remain a high index of suspicion for antiVGKC-associated disorders in cases where there are transient neurological disturbances in atypical spatial and temporal distributions.
摘要
自身免疫性电压门控钾通道病代表了一系列广泛且不断扩大的神经系统疾病。我们报告一例病例，展示了抗电压门控钾通道（VGKC）相关疾病的表型异质性。此类病例在初次就诊时很容易被误诊为功能性疾病。我们建议，对于非典型时空分布出现短暂神经功能障碍的病例，必须高度怀疑抗VGKC相关疾病。
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