Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA.
Biol Chem. 2013 Feb;394(2):231-8. doi: 10.1515/hsz-2012-0217.
Hepcidin is an iron regulatory protein mainly synthesized by the liver. Hepatocyte production of hepcidin is responsible for serum hepcidin, is responsive to body iron stores, and is critical for maintaining iron homeostasis. Monocytes and macrophages also express hepcidin, and in contrast to the liver, hepcidin expression is primarily regulated by inflammatory mediators and infectious agents. Monocyte and macrophage hepcidin is likely to be more important on a local rather than systemic level, contributes to host defense and may modulate inflammatory processes. This review summarizes recent findings and hypotheses on the relationship of hepcidin to the mononuclear phagocyte system.
亚铁调素是一种主要由肝脏合成的铁调节蛋白。肝细胞产生的亚铁调素负责血清中的亚铁调素，对体内铁储存有反应，对维持铁平衡至关重要。单核细胞和巨噬细胞也表达亚铁调素，与肝脏不同，亚铁调素的表达主要受炎症介质和感染因子的调节。单核细胞和巨噬细胞中的亚铁调素可能在局部而非全身水平更为重要，有助于宿主防御，并可能调节炎症过程。本综述总结了关于亚铁调素与单核吞噬细胞系统关系的最新发现和假说。
