Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China.
J Cardiovasc Med (Hagerstown). 2013 Jun;14(6):461-5. doi: 10.2459/JCM.0b013e32835dbd24.
Circulating surfactant protein D (SP-D) has been proved to be associated with cardiovascular disease and total mortality in European patients with coronary artery disease (CAD). This study was to determine whether serum SP-D levels are associated with 1-year prognosis in patients with chronic kidney disease (CKD) in a Chinese population.
Serum SP-D levels were examined by ELISA kit in 264 patients undergoing coronary angiography. An estimated glomerular filtration rate (eGFR) was used to determine the presence of CKD. Gensini scores were calculated to reflect the severity of coronary lesions. The correlations between SP-D, Gensini scores, white blood cells, high-sensitivity C-reactive protein (hs-CRP) and eGFR were calculated. Patients with eGFR less than 60 ml/min per 1.73 m2 were followed up for an average of 14 months, and major adverse cardiac events (MACEs) were recorded and analyzed.
Patients with CKD compared with patients without CKD were more often men, with a higher prevalence of hypertension, CAD, average age, levels of fasting glucose, hs-CRP and SP-D (179.73 ± 72.80 versus 131.65 ± 94.29 ng/ml; all P < 0.05). Serum SP-D levels were positively correlated with Gensini scores and eGFR, but not with white blood cells or hs-CRP. CKD patients suffering from MACEs had higher levels of serum SP-D (217.02 ± 102.34 versus 172.26 ± 70.27 ng/ml) and patients with SP-D at least 200 ng/ml had higher risk of MACEs (all P < 0.05). Multivariable analysis showed that smoking, multivessel disease, CKD and SP-D (OR: 1.396, 95% CI: 1.058-2.718, P = 0.028) were associated with 1-year MACEs (all P < 0.05).
SP-D levels are associated with 1-year prognosis in patients with CKD.
循环表面活性剂蛋白 D（SP-D）已被证明与欧洲冠状动脉疾病（CAD）患者的心血管疾病和总死亡率相关。本研究旨在确定在中国人群中，血清 SP-D 水平是否与慢性肾脏病（CKD）患者的 1 年预后相关。
通过 ELISA 试剂盒检测 264 例接受冠状动脉造影的患者的血清 SP-D 水平。使用估计肾小球滤过率（eGFR）来确定 CKD 的存在。计算 Gensini 评分以反映冠状动脉病变的严重程度。计算 SP-D、Gensini 评分、白细胞、高敏 C 反应蛋白（hs-CRP）和 eGFR 之间的相关性。eGFR 小于 60 ml/min/1.73 m2 的患者进行平均 14 个月的随访，记录并分析主要不良心脏事件（MACE）。
与无 CKD 的患者相比，CKD 患者中男性更多，高血压、CAD、平均年龄、空腹血糖、hs-CRP 和 SP-D 水平更高（179.73 ± 72.80 与 131.65 ± 94.29 ng/ml；均 P < 0.05）。血清 SP-D 水平与 Gensini 评分和 eGFR 呈正相关，但与白细胞或 hs-CRP 无关。发生 MACE 的 CKD 患者的血清 SP-D 水平更高（217.02 ± 102.34 与 172.26 ± 70.27 ng/ml），SP-D 至少为 200 ng/ml 的患者发生 MACE 的风险更高（均 P < 0.05）。多变量分析显示，吸烟、多血管疾病、CKD 和 SP-D（OR：1.396，95%CI：1.058-2.718，P = 0.028）与 1 年 MACE 相关（均 P < 0.05）。
SP-D 水平与 CKD 患者的 1 年预后相关。
