Neural correlates of stimulus spatial frequency-dependent contrast detection.

UNLABELLED

Psychophysical studies on human and non-human vertebrate species have shown that visual contrast sensitivity function (CSF) peaks at a certain stimulus spatial frequency and declines in both lower and higher spatial frequencies. The underlying neural substrate and mechanisms remain in debate. Here, we investigated the role of primary visual cortex (V1: area 17) in spatial frequency-dependent contrast detection in cats. Perceptual CSFs of three cats were measured using a two-alternative forced-choice task. The responses of V1 neurons to their optimal visual stimuli in a range of luminance contrast levels (from 0 to 1.0) were recorded subsequently using in vivo extracellular single-unit recording techniques. The contrast sensitivity of each neuron was determined. The neuronal CSF for each cat was constructed from the mean contrast sensitivity of neurons with different preferred stimulus spatial frequencies.

RESULT

(1) The perceptual and neuronal CSFs of each of the three cats exhibited a similar shape with peak amplitude near 0.4 cpd. (2) The neuronal CSF of each cat was highly correlated with its perceptual CSF. (3) V1 neurons with different preferred stimulus spatial frequencies had different contrast gains.

CONCLUSION

(1) Contrast detection of visual stimuli with different spatial frequencies may likely involve population coding of V1 neurons with different preferred stimulus spatial frequencies. (2) Difference in contrast gain may underlie the observed contrast sensitivity variation of V1 neurons with different preferred stimulus spatial frequencies, possibly from either evolution or postnatal visual experiences.