脑啡肽类似物FK 33 - 824产生的多巴胺介导行为。

Dopamine-mediated behavior produced by the enkephalin analogue FK 33-824.

作者信息

Extein I, Lo C, Goodwin F K, Schoenfeld R I

出版信息

Psychiatry Res. 1979 Dec;1(3):333-9. doi: 10.1016/0165-1781(79)90015-5.

Abstract

Intraperitoneal injection of FK 33-824 produced apomorphine-like stereotyped behavior in rats. Antagonism of this stereotypy by naloxone and neuroleptics suggests that FK 33-824 can activate opiate and dopamine receptors in the brain. Because increased dopaminergic neuronal activity is thought to be involved in schizophrenia and dopamine-mediated stereotypy has been used as an animal model for this illness, these results are consistent with an involvement of endogenous opiate-like peptides in schizophrenia. This involvement provides a possible mechanism for the reported improvement in schizophrenic psychosis produced by naloxone.

摘要

腹腔注射FK 33-824可使大鼠产生阿扑吗啡样的刻板行为。纳洛酮和抗精神病药物对这种刻板行为的拮抗作用表明，FK 33-824可激活大脑中的阿片受体和多巴胺受体。由于多巴胺能神经元活动增加被认为与精神分裂症有关，且多巴胺介导的刻板行为已被用作该疾病的动物模型，因此这些结果与内源性阿片样肽参与精神分裂症的发病过程是一致的。这种参与为纳洛酮治疗精神分裂症精神病的报道疗效提供了一种可能的机制。