Nakamura H
Department of Anatomy, Hiroshima University School of Medicine, Japan.
Brain Res. 1990 Mar 12;511(1):122-8. doi: 10.1016/0006-8993(90)90231-y.
Heterotopic transplantations of brain vesicles of a quail embryo into a chick embryo were carried out in order to elucidate if CNS anlagen have plasticity in differentiation at the 7-10 somite stage. Quail cells are distinguished from chick cells due to the difference in nuclear morphology. The prosencephalon did not differentiate into the cerebellum when transplanted into the metencephalon, although previous study showed that the prosencephalon has the capacity to differentiate into the optic tectum. The mesencephalon differentiated as an optic tectum when transplanted into the prosencephalon or into the rhombencephalon. The metencephalon differentiated as a cerebellum in the telencephalon. It is concluded that only the prosencephalon has limited plasticity, but the mesencephalon and rhombencephalon are determined by the 7-10 somite stage.
为了阐明中枢神经系统原基在7 - 10体节期是否具有分化可塑性，将鹌鹑胚胎的脑泡异位移植到鸡胚胎中。由于核形态的差异，鹌鹑细胞与鸡细胞得以区分。前脑移植到后脑时并未分化为小脑，尽管先前的研究表明前脑有分化为视顶盖的能力。中脑移植到前脑或菱脑时分化为视顶盖。后脑在端脑内分化为小脑。结论是只有前脑具有有限的可塑性，而中脑和菱脑在7 - 10体节期就已确定。
