帕金森病体外研究：患者特异性重编程体细胞核细胞能告诉我们帕金森病的什么？如果有的话？
Parkinson's Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson's Disease, If Anything?
机构信息
Neuroscience Axis, CHUL Research Center (CHUQ), T2-50, 2705 Boul. Laurier, Quebec City, QC, Canada G1V 4G2.
出版信息
Stem Cells Int. 2012;2012:926147. doi: 10.1155/2012/926147. Epub 2012 Dec 20.
Abstract
Technologies allowing for the derivation of patient-specific neurons from somatic cells are emerging as powerful in vitro tools to investigate the intrinsic cellular pathological behaviours of the diseases that affect these patients. While the use of patient-derived neurons to model Parkinson's disease (PD) has only just begun, these approaches have allowed us to begin investigating disease pathogenesis in a unique way. In this paper, we discuss the advances made in the field of cellular reprogramming to model PD and discuss the pros and cons associated with the use of such cells.
摘要
从体细胞中衍生出患者特异性神经元的技术正在成为研究影响这些患者疾病的内在细胞病理行为的强大体外工具。虽然使用患者来源的神经元来模拟帕金森病（PD）才刚刚开始，但这些方法使我们能够以独特的方式开始研究疾病的发病机制。在本文中，我们讨论了在细胞重编程领域取得的进展，以模拟 PD，并讨论了使用此类细胞的优缺点。
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