阿片肽：药物开发潜力
Opioid Peptides: Potential for Drug Development.
作者信息
Aldrich Jane V, McLaughlin Jay P
机构信息
Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045.
出版信息
Drug Discov Today Technol. 2012;9(1):e23-e31. doi: 10.1016/j.ddtec.2011.07.007.
Abstract
Opioid receptors are important targets for the treatment of pain and potentially for other disease states (e.g. mood disorders and drug abuse) as well. Significant recent advances have been made in identifying opioid peptide analogs that exhibit promising in vivo activity for treatment of these maladies. This review focuses on the development and evaluation of opioid peptide analogs demonstrating activity after systemic administration, and recent clinical evaluations of opioid peptides for possible therapeutic use.
摘要
阿片受体是治疗疼痛的重要靶点，也可能是治疗其他疾病状态（如情绪障碍和药物滥用）的靶点。最近在鉴定阿片肽类似物方面取得了重大进展，这些类似物在体内对治疗这些疾病显示出有前景的活性。本综述重点关注全身给药后显示活性的阿片肽类似物的开发和评估，以及阿片肽用于可能治疗用途的近期临床评估。
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