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停用甲氨蝶呤并给予克拉霉素后，甲氨蝶呤相关的爱泼斯坦-巴尔病毒相关霍奇金样淋巴瘤完全缓解

Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration.

作者信息

Takemori Nobuo, Kaneko Hiroyuki, Nakamura Masaya, Kojima Masaru

机构信息

Division of Hematology, Department of Internal Medicine, Imai Hospital, Tanaka-cho 100, Ashikaga, Tochigi 326-0822, Japan.

出版信息

Case Rep Hematol. 2012;2012:658745. doi: 10.1155/2012/658745. Epub 2012 Dec 19.

DOI:10.1155/2012/658745
PMID:23316401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3535817/
Abstract

Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin's lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission.

摘要

已知类风湿性关节炎（RA）患者在病程中会发生淋巴增殖性疾病（LPD），尤其是长期接受甲氨蝶呤（MTX）治疗的患者。我们描述了一例与MTX相关的、由爱泼斯坦-巴尔病毒（EBV）引起的LPD，其临床表现类似霍奇金淋巴瘤（HL），在停用MTX并给予克拉霉素（CAM）后，病情戏剧性地完全缓解。停用MTX并给予CAM似乎对治疗与MTX相关的EBV相关性LPD有效。特别是，CAM的免疫调节作用可能参与了实现完全缓解的过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/dd1f1e608768/CRIM.HEMATOLOGY2012-658745.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/6672ad08fc8a/CRIM.HEMATOLOGY2012-658745.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/57a5a69a4940/CRIM.HEMATOLOGY2012-658745.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/dd1f1e608768/CRIM.HEMATOLOGY2012-658745.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/6672ad08fc8a/CRIM.HEMATOLOGY2012-658745.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/57a5a69a4940/CRIM.HEMATOLOGY2012-658745.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14cd/3535817/dd1f1e608768/CRIM.HEMATOLOGY2012-658745.003.jpg

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