El-Sitt Sally, El-Sibai Mirvat
Department of Natural Sciences, Lebanese American University, Beirut Campus, Beirut, Lebanon.
J Recept Signal Transduct Res. 2013;33(1):10-3. doi: 10.3109/10799893.2012.752002. Epub 2013 Jan 15.
RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute one of the major classes of regulators of RhoGTPases. They act as negative regulators of the RhoGTPases by enhancing their slow intrinsic GTPase activity. STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13.
RhoGTPases被定义为一个由20种小G蛋白组成的家族，在几乎每个细胞过程中都发挥着重要作用。RhoGTPases是鸟嘌呤核苷酸结合蛋白，以两种形式存在：结合GTP的活性形式和结合GDP的非活性形式。被称为RhoGAPs的RhoGTPase激活蛋白构成了RhoGTPases主要的调节因子类别之一。它们通过增强RhoGTPases缓慢的内在GTPase活性，作为RhoGTPases的负调节因子。STARD13是一种RhoGTPases的GTPase激活蛋白（GAP），已被描述为肝细胞癌中的一种肿瘤抑制因子。在本综述中，我们讨论了RhoGTPases家族、它们的调节及其RhoGAPs，主要聚焦于STARD13。
