Donohue Katelyn, Cox Jennifer L, Dwyer Michael G, Aliotta Rachel, Corwin Melanie, Weinstock-Guttman Bianca, Ann Yeh E, Zivadinov Robert
SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY; Buffalo Neuroimaging Analysis Center, Buffalo, NY.
J Neuroimaging. 2014 Jan-Feb;24(1):63-7. doi: 10.1111/j.1552-6569.2012.00775.x. Epub 2013 Jan 14.
To investigate differences in region-specific gray matter (GM) damage between adults with pediatric-onset (PO) multiple sclerosis (MS) and adult-onset (AO) MS.
Twenty-four relapsing-remitting (RR) adults with POMS (mean age = 35 years, mean disease duration = 18.4 years) were compared to 23 age-matched (AOA, mean age = 33.9 years, mean disease duration = 2.4 years) and 24 disease-duration matched (AOD, mean age = 45.9 years, mean disease duration = 18.5 years) RRMS adults who developed MS after the age of 18. Three-dimensional-T1-weighted images were acquired on a 1.5 T MRI. Image analysis was conducted using voxel-based morphometry (Statistical Parametric Mapping 8).
There were no regional GM atrophy differences between POMS and AODMS groups. No regional GM atrophy differences were found between POMS and AOAMS patients when disease duration was included as a covariate.
Regional GM differences were not found between POMS adults and MS controls matched for age or disease duration. Although of limited sample size, these findings suggest that there are no regional GM atrophy differences between RR POMS and AOMS.
研究儿童期起病（PO）的多发性硬化（MS）成年患者与成年期起病（AO）的MS成年患者在特定脑区灰质（GM）损伤方面的差异。
将24例复发缓解型（RR）儿童期起病的MS成年患者（平均年龄 = 35岁，平均病程 = 18.4年）与23例年龄匹配（AOA，平均年龄 = 33.9岁，平均病程 = 2.4年）以及24例病程匹配（AOD，平均年龄 = 45.9岁，平均病程 = 18.5年）的18岁后发病的RRMS成年患者进行比较。在1.5T磁共振成像仪上采集三维T1加权图像。使用基于体素的形态测量法（统计参数映射8）进行图像分析。
儿童期起病的MS组与病程匹配的MS组之间在脑区GM萎缩方面无差异。将病程作为协变量纳入分析时，儿童期起病的MS患者与年龄匹配的成年期起病的MS患者之间在脑区GM萎缩方面也未发现差异。
在年龄或病程匹配的儿童期起病的MS成年患者与MS对照组之间未发现脑区GM差异。尽管样本量有限，但这些结果表明复发缓解型儿童期起病的MS与成年期起病的MS之间在脑区GM萎缩方面无差异。
