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重新审视真核抗感染生物疗法。

Revisiting eukaryotic anti-infective biotherapeutics.

作者信息

Rishi Praveen, Singh Aman Preet, Arora Sumeha, Garg Neha, Kaur Indu Pal

机构信息

Department of Microbiology, Panjab University , Chandigarh, Chandigarh , India and.

出版信息

Crit Rev Microbiol. 2014 Nov;40(4):281-92. doi: 10.3109/1040841X.2012.749210. Epub 2013 Jan 15.

Abstract

Emerging drug resistance has forced the scientific community to revisit the observational data documented in the folklore and come up with novel and effective alternatives. Candidates from eukaryotic origin including herbal products and antimicrobial peptides are finding a strategic place in the therapeutic armamentarium against infectious diseases. These agents have recently gained interest owing to their versatile applications. Present review encompasses the use of these alternative strategies in their native or designer form, alone or in conjunction with antibiotics, as possible remedial measures. Further to this, the limitations or the possible concerns associated with these options are also discussed at length.

摘要

新出现的耐药性迫使科学界重新审视民间传说中记录的观察数据,并提出新颖有效的替代方案。包括草药产品和抗菌肽在内的真核生物来源的候选药物正在抗传染病治疗药物中占据一席之地。这些药物因其广泛的应用最近受到了关注。本综述涵盖了这些替代策略以其天然或设计形式单独使用或与抗生素联合使用作为可能的补救措施的情况。此外,还详细讨论了与这些选择相关的局限性或可能存在的问题。

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