Department of Rheumatology, People's Hospital of Zhengzhou, Zhengzhou 450000, China.
Asian Pac J Trop Med. 2013 Jan;6(1):73-5. doi: 10.1016/S1995-7645(12)60204-1.
To discuss the association between single nucleotide polymorphism (SNP) of rs3811047 in IL-1 F7 gene and rheumatoid arthritis (RA) susceptibility among the Han population in central plains of China.
A total of 276 RA patients admitted to our hospital from December 2009 to December 2011 together with 276 healthy physical examinees in the same period were chosen as the subjects. The typing for rs3811047 SNP in IL-1 F7 gene was carried out by using ligase detection reaction and polymerase chain reaction technique. And the frequency of each allele and genotypes distribution was calculated so as to evaluate the association between genotype distribution and RA susceptibility.
The frequency of A allele of rs3811047 in IL-1 F7 gene in RA group and control group was 16.27% and 17.68%, respectively, and that of G allele in two groups was 83.73% and 82.32%, respectively. The difference between two groups wasn't statistical significant (P >0.05). The frequency of genotype AA, AG and GG in RA group was 2.19%, 27.84% and 69.97%, respectively, while that in control group was 2.94%, 29.78% and 67.28%, respectively. The difference of distribution of three genotypes was not statistically significant (P >0.05). RA patients with A allele were better than those without A allele in joint swelling index, rest pain, HAQ scoring and blood sedimentation. There was significant difference between two groups in above indexes (P<0.05/P<0.01).
No significant correlation between RA susceptibility among the Han population in central plains of China and rs3811047 SNP inIL-1 F7 gene is observed. However, A allele of rs3811047 has certain influence on the condition of RA patients.
探讨中国中原地区汉族人群白细胞介素-1 F7 基因 rs3811047 单核苷酸多态性（SNP）与类风湿关节炎（RA）易感性的关系。
选取 2009 年 12 月至 2011 年 12 月我院收治的 276 例 RA 患者和同期 276 例健康体检者为研究对象，采用连接酶检测反应和聚合酶链反应技术对 rs3811047 基因 IL-1 F7 基因 SNP 进行分型，计算各等位基因和基因型分布频率，评估基因型分布与 RA 易感性的关系。
RA 组和对照组 rs3811047 基因 IL-1 F7 中 A 等位基因频率分别为 16.27%和 17.68%，G 等位基因频率分别为 83.73%和 82.32%，两组间差异无统计学意义（P>0.05）。RA 组 AA、AG 和 GG 基因型频率分别为 2.19%、27.84%和 69.97%，对照组分别为 2.94%、29.78%和 67.28%，三组基因型分布差异无统计学意义（P>0.05）。A 等位基因 RA 患者的关节肿胀指数、休息痛、HAQ 评分和血沉均优于无 A 等位基因者，两组间差异有统计学意义（P<0.05/P<0.01）。
中国中原地区汉族人群 RA 易感性与 IL-1 F7 基因 rs3811047 SNP 无明显相关性，但 rs3811047 基因 A 等位基因对 RA 患者病情有一定影响。
