Bunch S T, Fawcett J W
Physiological Laboratory, Cambridge, U.K.
Brain Res Dev Brain Res. 1990 Mar 1;52(1-2):259-64. doi: 10.1016/0165-3806(90)90243-r.
Newborn albino and pigmented rats received localised Fast blue (FB) injections into the most caudal part of the contralateral superior colliculus (SC). A proportion of retinal ganglion cells (RGC's) from the temporal retina which in the adult projects exclusively to the rostral half of the colliculus are labelled by injections to the caudal colliculus in neonatal animals. The majority of these cells die during the period of naturally occurring cell death in the retina, which occurs during the first 10 postnatal days. The object of this experiment was to see whether albino rats, which have well documented abnormalities in axon pathfinding in their visual system, had a larger number of cells in temporal retina which initially project to caudal colliculus than pigmented animals. On postnatal day 2 (P2), the ratio of temporal to nasal RGCs projecting to the caudal SC is greater in albino than pigmented rats (6.2% vs 2.65%). After the wave of naturally occurring cell death, at P14, when many of the neonatal errors have been eliminated, the ratio of temporal to nasal RGC's is reduced to 1.71% for albinos versus 1.53% for pigmented rats.
新生白化大鼠和有色大鼠在对侧上丘（SC）最尾端接受局部快蓝（FB）注射。成年后仅投射到上丘 Rostral 半部分的颞侧视网膜的一部分视网膜神经节细胞（RGC），在新生动物中通过向尾侧上丘注射而被标记。这些细胞中的大多数在视网膜自然发生细胞死亡期间死亡，该过程发生在出生后的前 10 天。本实验的目的是观察在视觉系统轴突寻路方面有充分记录异常的白化大鼠，其颞侧视网膜中最初投射到尾侧上丘的细胞数量是否比有色动物更多。在出生后第 2 天（P2），投射到尾侧 SC 的颞侧与鼻侧 RGC 的比例在白化大鼠中比有色大鼠更高（6.2% 对 2.65%）。在自然发生的细胞死亡浪潮之后，在 P14 时，当许多新生期的错误已经消除时，白化大鼠颞侧与鼻侧 RGC 的比例降至 1.71%，而有色大鼠为 1.53%。
