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肥胖与心脏：减肥手术有益效果的心血管磁共振成像证据

Obesity and the heart: cardiovascular magnetic resonance imaging evidence of the beneficial effects of bariatric surgery.

作者信息

Rider Oliver J, Byrne James P, Neubauer Stefan

机构信息

Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, UK.

出版信息

JSLS. 2012 Jul-Sep;16(3):466-8. doi: 10.4293/108680812X13462882735935.

DOI:10.4293/108680812X13462882735935
PMID:23318075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3535810/
Abstract

Obesity is associated with cardiac hypertrophy and increased aortic stiffness, which are independent predictors of cardiovascular risk. In the setting of obesity, bariatric surgical weight loss has been shown to reduce mortality. We present a case showing that, in a severely obese individual without comorbidities, these cardiovascular responses to excess weight are reversible during weight loss over a period of 1 year.

摘要

肥胖与心脏肥大和主动脉僵硬度增加有关，而这两者都是心血管风险的独立预测因素。在肥胖的情况下，减肥手术已被证明可降低死亡率。我们报告了一例病例，该病例显示，在一名无合并症的严重肥胖个体中，在一年的体重减轻期间，这些对超重的心血管反应是可逆的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c39b/3535810/3aa294272b51/jls0031229000001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c39b/3535810/3aa294272b51/jls0031229000001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c39b/3535810/3aa294272b51/jls0031229000001.jpg

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本文引用的文献

1
Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity.减肥手术和饮食性体重减轻对肥胖症患者心血管的有益影响。
J Am Coll Cardiol. 2009 Aug 18;54(8):718-26. doi: 10.1016/j.jacc.2009.02.086.
2
Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study.肥胖症患者左心室质量的决定因素；一项心血管磁共振研究。
J Cardiovasc Magn Reson. 2009 Apr 24;11(1):9. doi: 10.1186/1532-429X-11-9.
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Long-term mortality after gastric bypass surgery.胃旁路手术后的长期死亡率。
N Engl J Med. 2007 Aug 23;357(8):753-61. doi: 10.1056/NEJMoa066603.
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Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.一个50至71岁人群的大型前瞻性队列研究中的超重、肥胖与死亡率
N Engl J Med. 2006 Aug 24;355(8):763-78. doi: 10.1056/NEJMoa055643. Epub 2006 Aug 22.
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Outcome of heart failure with preserved ejection fraction in a population-based study.一项基于人群的射血分数保留的心力衰竭研究结果
N Engl J Med. 2006 Jul 20;355(3):260-9. doi: 10.1056/NEJMoa051530.
6
Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study.动脉僵硬度与冠心病和中风风险：鹿特丹研究
Circulation. 2006 Feb 7;113(5):657-63. doi: 10.1161/CIRCULATIONAHA.105.555235.
7
The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes.肥胖相关肽瘦素可诱导新生大鼠心室肌细胞肥大。
Circ Res. 2003 Aug 22;93(4):277-9. doi: 10.1161/01.RES.0000089255.37804.72. Epub 2003 Jul 31.
8
Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition.在参与健康、衰老和身体成分研究的老年人中，主动脉僵硬度与内脏脂肪过多有关。
Hypertension. 2001 Sep;38(3):429-33. doi: 10.1161/01.hyp.38.3.429.
9
Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome.肥胖性心肌病：临床综合征的病理生理学与演变
Am J Med Sci. 2001 Apr;321(4):225-36. doi: 10.1097/00000441-200104000-00003.
10
Prognostic implications of left ventricular hypertrophy.左心室肥厚的预后意义。
Am Heart J. 2001 Mar;141(3):334-41. doi: 10.1067/mhj.2001.113218.