Rotge Jean-Yves, Langbour Nicolas, Dilharreguy Bixente, Bordessoulles Martine, Guehl Dominique, Bioulac Bernard, Martin-Guehl Corinne, Jaafari Nematollah, Aouizerate Bruno, Allard Michele, Burbaud Pierre
Institut des Maladies Neurodégénératives, CNRS UMR 5293, Bordeaux, France; Université Victor Segalen Bordeaux 2, Bordeaux, France; Pôle Universitaire de Psychiatrie Adulte, Hôpital Charles Perrens, Bordeaux, France.
Institut des Maladies Neurodégénératives, CNRS UMR 5293, Bordeaux, France; Université Victor Segalen Bordeaux 2, Bordeaux, France.
Cortex. 2015 Jan;62:1-10. doi: 10.1016/j.cortex.2012.12.010. Epub 2012 Dec 23.
Behavioral adaptation generally follows the contextual changes arising from the consequences (rewards and punishments) of an action. According to the reciprocal determinism model, there is a mutual influence between external context, cognitive processes and behavior. The maladaptive behaviors observed in obsessive-compulsive disorder (OCD) have been hypothesized to result from the disruption of the interactions between these three entities. For this, we assessed the influence of error signals and checking behavior on prefrontal cortical functions during decision-making in 14 OCD patients and 14 matched healthy participants.
We used a behavioral task designed to elicit intolerance of uncertainty (IU) followed by the free expression of checking behaviors, which was coupled with functional magnetic resonance imaging.
At the behavioral level, IU intensity was correlated to the number of checking behaviors in both checking OCD patients and healthy controls during decision-making. However, external error signals did not influence checking behaviors in OCD patients, whereas they appeared to trigger checking behaviors in healthy subjects. At the neural level, IU intensity was positively correlated with activation in the orbitofrontal cortex (OFC) in both the OCD and control groups. At the region of interest (ROI) level, error signals increased IU-related OFC activations; in contrast, checking behaviors contributed to decreasing these neural activations in the healthy subjects, but no such modulation was observed in the OCD patients.
Our results show that IU-related OFC dysfunctions are not under the influence of the context and the behavioral response in OCD, suggesting that alterations of the dynamic features for this neural network may contribute to the expression of OCD symptoms.
行为适应通常遵循因行为后果（奖励和惩罚）而产生的情境变化。根据相互决定论模型，外部情境、认知过程和行为之间存在相互影响。强迫症（OCD）中观察到的适应不良行为被假设是由这三个实体之间相互作用的破坏所致。为此，我们评估了错误信号和检查行为对14名强迫症患者和14名匹配的健康参与者在决策过程中前额叶皮层功能的影响。
我们使用了一项行为任务，旨在引发对不确定性的不耐受（IU），随后自由表达检查行为，并结合功能磁共振成像。
在行为层面，在决策过程中，检查强迫症患者和健康对照组中，IU强度与检查行为的数量相关。然而，外部错误信号并未影响强迫症患者的检查行为，而在健康受试者中它们似乎会引发检查行为。在神经层面，OCD组和对照组中IU强度均与眶额皮质（OFC）的激活呈正相关。在感兴趣区域（ROI）层面，错误信号增加了与IU相关的OFC激活；相反，检查行为有助于降低健康受试者中的这些神经激活，但在强迫症患者中未观察到这种调节。
我们的结果表明，与IU相关的OFC功能障碍不受OCD中情境和行为反应的影响，这表明该神经网络动态特征的改变可能有助于OCD症状的表达。
