Niu Qihui, Yang Lei, Song Xueqin, Chu Congying, Liu Hao, Zhang Lifang, Li Yan, Zhang Xiang, Cheng Jingliang, Li Youhui
Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou.
Brainnetome Certer, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China.
Neuropsychiatr Dis Treat. 2017 Feb 16;13:507-513. doi: 10.2147/NDT.S117510. eCollection 2017.
This paper attempts to explore the brain activity of patients with obsessive-compulsive disorder (OCD) and its correlation with the disease at resting duration in patients with first-episode OCD, providing a forceful imaging basis for clinic diagnosis and pathogenesis of OCD.
Twenty-six patients with first-episode OCD and 25 healthy controls (HC group; matched for age, sex, and education level) underwent functional magnetic resonance imaging (fMRI) scanning at resting state. Statistical parametric mapping 8, data processing assistant for resting-state fMRI analysis toolkit, and resting state fMRI data analysis toolkit packages were used to process the fMRI data on Matlab 2012a platform, and the difference of regional homogeneity (ReHo) values between the OCD group and HC group was detected with independent two-sample -test. With age as a concomitant variable, the Pearson correlation analysis was adopted to study the correlation between the disease duration and ReHo value of whole brain.
Compared with HC group, the ReHo values in OCD group were decreased in brain regions, including left thalamus, right thalamus, right paracentral lobule, right postcentral gyrus, and the ReHo value was increased in the left angular gyrus region. There was a negative correlation between disease duration and ReHo value in the bilateral orbitofrontal cortex (OFC).
OCD is a multifactorial disease generally caused by abnormal activities of many brain regions at resting state. Worse brain activity of the OFC is related to the OCD duration, which provides a new insight to the pathogenesis of OCD.
探讨首发强迫症（OCD）患者静息状态下的脑活动及其与疾病的相关性，为OCD的临床诊断和发病机制提供有力的影像学依据。
26例首发OCD患者和25名健康对照者（HC组，年龄、性别和教育水平相匹配）在静息状态下接受功能磁共振成像（fMRI）扫描。使用统计参数映射8、静息态fMRI分析工具包的数据处理助手以及静息态fMRI数据分析工具包在Matlab 2012a平台上处理fMRI数据，采用独立两样本t检验检测OCD组和HC组之间局部一致性（ReHo）值的差异。以年龄作为伴随变量，采用Pearson相关分析研究病程与全脑ReHo值之间的相关性。
与HC组相比，OCD组左侧丘脑、右侧丘脑、右侧中央旁小叶、右侧中央后回等脑区的ReHo值降低，左侧角回区域的ReHo值升高。双侧眶额皮质（OFC）的病程与ReHo值之间存在负相关。
OCD是一种多因素疾病，通常由静息状态下多个脑区的异常活动引起。OFC较差的脑活动与OCD病程相关，这为OCD的发病机制提供了新的见解。
