Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Trends Neurosci. 2013 Feb;36(2):65-73. doi: 10.1016/j.tins.2012.12.005. Epub 2013 Jan 12.
The past 20 years witnessed an enormous leap in understanding of the central regulation of whole-body energy metabolism. Genetic tools have enabled identification of the region-specific expression of peripheral metabolic hormone receptors and have identified neuronal circuits that mediate the action of these hormones on behavior and peripheral tissue functions. One of the surprising findings of recent years is the observation that brain circuits involved in metabolism regulation remain plastic through adulthood. In this review, we discuss these findings and focus on the role of neurons and glial cells in the dynamic process of plasticity, which is fundamental to the regulation of physiological and pathological metabolic events.
过去的 20 年见证了人们对全身能量代谢的中枢调节的理解的巨大飞跃。遗传工具使人们能够识别外周代谢激素受体的区域特异性表达，并确定了介导这些激素对行为和外周组织功能作用的神经元回路。近年来令人惊讶的发现之一是，参与代谢调节的大脑回路在成年期仍具有可塑性。在这篇综述中，我们讨论了这些发现，并重点介绍了神经元和神经胶质细胞在可塑性的动态过程中的作用，这对生理和病理代谢事件的调节至关重要。
