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Liver cancer: Intrahepatic cholangiocarcinoma--appearances can be deceiving.

作者信息

Alison Malcolm R, Lin Wey-Ran

机构信息

Centre for Tumour Biology, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.

出版信息

Nat Rev Gastroenterol Hepatol. 2013 Mar;10(3):131-3. doi: 10.1038/nrgastro.2012.258. Epub 2013 Jan 15.

DOI:10.1038/nrgastro.2012.258
PMID:23318263
Abstract
摘要

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The cellular origins of cancer with particular reference to the gastrointestinal tract.癌症的细胞起源，特别是胃肠道。
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本文引用的文献

1
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes.肝内胆管癌可源于 Notch 介导的肝细胞转化。
J Clin Invest. 2012 Nov;122(11):3914-8. doi: 10.1172/JCI63065.
2
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.巨噬细胞衍生的 Wnt 信号拮抗 Notch 信号以在慢性肝病中特异性地决定肝祖细胞命运。
Nat Med. 2012 Mar 4;18(4):572-9. doi: 10.1038/nm.2667.
3
Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes.
胆管细胞癌的组织学多样性反映了不同的胆管细胞表型。
Hepatology. 2012 Jun;55(6):1876-88. doi: 10.1002/hep.25595.
4
Human hepatic stem cell and maturational liver lineage biology.人类肝干细胞和成熟肝谱系生物学。
Hepatology. 2011 Mar;53(3):1035-45. doi: 10.1002/hep.24157.
5
Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation.肝细胞向胆管上皮细胞转分化过程中再生胆管内肝细胞和胆管特异性转录因子的表达
Comp Hepatol. 2010 Dec 2;9:9. doi: 10.1186/1476-5926-9-9.
6
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.上皮细胞黏附分子（EpCAM）和甲胎蛋白表达定义了肝细胞癌新的预后亚型。
Cancer Res. 2008 Mar 1;68(5):1451-61. doi: 10.1158/0008-5472.CAN-07-6013.
7
Metaplasia and transdifferentiation: from pure biology to the clinic.化生与转分化：从纯粹生物学走向临床应用
Nat Rev Mol Cell Biol. 2007 May;8(5):369-78. doi: 10.1038/nrm2146. Epub 2007 Mar 21.
8
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.一种源自肝祖细胞的人类肝细胞癌新预后亚型。
Nat Med. 2006 Apr;12(4):410-6. doi: 10.1038/nm1377. Epub 2006 Mar 12.
9
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury.胆管结扎和毒性胆管损伤后大鼠肝细胞向胆管细胞的转分化
Hepatology. 2005 Mar;41(3):535-44. doi: 10.1002/hep.20600.
10
Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.干细胞分化的成熟停滞是畸胎癌和上皮癌细胞起源的常见途径。
Lab Invest. 1994 Jan;70(1):6-22.