Merlob P, Litwin A, Lazar L, Zaizov R
Department of Neonatology, Beilinson Medical Center, Petah Tikva, Israel.
Clin Pediatr (Phila). 1990 Apr;29(4):219-22. doi: 10.1177/000992289002900403.
The authors present two infants with isoimmune hemolytic disease due to ABO incompatibility complicated by massive hemoglobinuria and secondary acute renal failure. This represents an incidence of 0.36% of all neonates with ABO hemolytic disease in the author's newborn population. Only two patients have been reported previously to have similar complications. Analysis of data of these four infants revealed the clinical characteristics of this complication of ABO incompatibility: 1) very low frequency; 2) early onset of hemoglobinuria (first voided urine) and of acute renal failure (first 2 days of life); 3) lack of correlation between the clinical presentation of hemolytic disease and appearance and severity of renal failure; 4) complete recovery of renal functions following intravenous fluid administration; and 5) normal renal radiologic investigations.
作者报告了两名患有ABO血型不合所致同族免疫性溶血病的婴儿，该病并发大量血红蛋白尿和继发性急性肾衰竭。这在作者所在新生儿群体中占所有ABO溶血病新生儿的0.36%。此前仅有两例患者报告有类似并发症。对这四名婴儿的数据分析揭示了ABO血型不合这一并发症的临床特征：1）发生率极低；2）血红蛋白尿（首次排尿）和急性肾衰竭（出生后前两天）发病早；3）溶血病的临床表现与肾衰竭的出现及严重程度之间缺乏相关性；4）静脉补液后肾功能完全恢复；5）肾脏影像学检查正常。
