Functioning of peripheral Ia pathways in infants with myelomeningocele.

The goal was to examine the accessibility of Ia-proprioceptive pathways to motoneurons of leg muscles associated with gait in infants with Myelomeningocele (MMC). Participants were 15 MMC infants, ages 2-10 months. We assessed over repeated trials, the tendon reflex (T-reflex), vibration-induced inhibition of T-reflex (VIM-T-reflex), and tonic vibration-induced reflex (VIR) when computer controlled stimuli were applied to the three gait muscles of each leg. Only one third of MMC infants exhibited motor responses following the mechanical stimuli with sufficient frequency to be judged functioning as in typically developing (TD) infants. Age and lesion level were not apparently associated with response frequency, but scores on the gross motor portion of the Bayley Scale was a reasonable predictor. For those in which responses were frequent, the pattern of reciprocal excitation was similar to that of age-matched TD infants. 4 of the 10 non-responders who were also tested for their responses to being supported on a pediatric treadmill in a companion study showed voluntary muscle activity in all three gait muscles and a vibration-induced contraction was observed for some of the non-responders. Ia-proprioceptive pathways to homonymous and heteronymous muscles are functioning in some MMC babies, but the gain setting of these pathways were generally depressed and for many there was no evidence that the pathways were intact, although for some group more functional stimuli may be needed to elicit responses and experience may be needed to enhance the gain on the sensitivity of these neural pathways. More research is needed to understand how to optimize outcomes via rehabilitation.