Department of Rehabilitation Medicine, Hannover Medical School, Hannover, Germany.
Neurochem Int. 2013 Feb;62(3):281-6. doi: 10.1016/j.neuint.2013.01.001. Epub 2013 Jan 11.
Brain-derived neurotrophic factor (BDNF) has been known to play a role in fibromyalgia syndrome (FMS) patients. Depression and anxiety are quite common additional symptoms in FMS. However the role of BDNF in these symptoms still needs to be elucidated. Although BDNF has been shown to be relevant in major depression, however studies could not show such differences between FMS patients with and without major depression. As mood-related symptom occurs frequently and differs in its intensity in FMS patients, BDNF level should be measured in subgroup regarding depression and anxiety scale. Therefore the aim of this study was to evaluate the correlation of BDNF in serum of FMS with intensity of depression and anxiety. Additionally, interleukin (IL)-6 was measured. This study showed that serum level of BDNF was age-dependent in HCs. FMS patients had higher level of serum BDNF as compared to HC. Additionally, serum level of BDNF showed correlation with depression, but not with anxiety. Serum level of BDNF increased with depression score in FMS. However, serum level of IL-6 was not correlated with both depression and anxiety scores. Taken together, BDNF is involved in the pathophysiology of FMS. Additionally, it seems to be correlated with intensity of depressive symptoms in FMS.
脑源性神经营养因子（BDNF）已被证明在纤维肌痛综合征（FMS）患者中发挥作用。抑郁和焦虑是 FMS 患者常见的附加症状。然而，BDNF 在这些症状中的作用仍需要阐明。尽管 BDNF 已被证明与重度抑郁症相关，但研究未能显示 FMS 患者中重度抑郁症与无重度抑郁症之间存在差异。由于情绪相关症状在 FMS 患者中经常发生且强度不同，因此应根据抑郁和焦虑量表对亚组测量 BDNF 水平。因此，本研究旨在评估 FMS 患者血清中 BDNF 与抑郁和焦虑强度的相关性。此外，还测量了白细胞介素（IL）-6。本研究表明，健康对照组（HCs）中 BDNF 的血清水平随年龄而变化。与 HCs 相比，FMS 患者的血清 BDNF 水平更高。此外，BDNF 血清水平与抑郁相关，但与焦虑无关。FMS 患者的 BDNF 血清水平随抑郁评分的增加而增加。然而，IL-6 的血清水平与抑郁和焦虑评分均无相关性。总之，BDNF 参与了 FMS 的病理生理学。此外，它似乎与 FMS 中抑郁症状的严重程度相关。
