Centre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.
Int J Obes (Lond). 2013 Sep;37(9):1247-53. doi: 10.1038/ijo.2012.214. Epub 2013 Jan 15.
Research examining the relationship between adiponectin (AN) isoforms, body weight and cardiovascular (CV) risk factors is limited, particularly in younger populations.
To investigate the inter-relationships between AN isoforms and CV risk factors, and their dependence on body weight status, in adolescents.
Blood samples from 92 obese, 92 overweight and 92 normal weight age- and sex-matched adolescents were analysed for traditional cardiovascular disease (CVD) risk biomarkers and also total, high molecular weight (HMW), medium and low molecular weight (LMW) AN.
A significant inverse association was observed between total and HMW AN and waist-hip ratio (P=0.015, P=0.006, respectively), triglycerides (P=0.003, P=0.003, respectively) and systolic blood pressure (P=0.012, P=0.024, respectively) and a significant positive association with high-density lipoprotein (P<0.001, P<0.001, respectively) in multi-adjusted analyses. There was no evidence of a relationship between multimeric AN and high-sensitivity C-reactive protein. There was also little evidence of a relationship between LMW AN and CVD risk factors. There was a strong, body mass index (BMI)-independent, association between AN, CVD biomarkers and the hypertriglyceridemic waist phenotype.
Prominent, BMI-independent associations between total and HMW AN, but not LMW AN, and CVD risk factors were already evident in this young population. This research in adolescents supports the contention that AN subfractions may have different biological actions. These associations in apparently healthy adolescents suggest an important role for AN and its subfractions in the pathogenesis of metabolic syndrome traits and indicate that the potential for total or HMW AN to act as early universal biomarkers of CV risk warrants further study.
研究脂肪素 (AN) 异构体与体重和心血管 (CV) 危险因素之间的关系的工作有限，尤其是在年轻人群中。
在青少年中研究 AN 异构体与 CV 危险因素之间的相互关系，及其与体重状态的依赖关系。
分析了 92 名肥胖、92 名超重和 92 名体重正常的青少年的血液样本，检测传统心血管疾病 (CVD) 风险生物标志物以及总、高分子量 (HMW)、中分子量 (MW) 和低分子量 (LMW) AN。
在多变量分析中，总 AN 和 HMW AN 与腰臀比呈显著负相关 (P=0.015，P=0.006)，与甘油三酯 (P=0.003，P=0.003) 和收缩压呈显著正相关 (P=0.012，P=0.024)，高密度脂蛋白呈显著正相关 (P<0.001，P<0.001)。多聚体 AN 与高敏 C 反应蛋白之间无关联。LMW AN 与 CVD 危险因素之间也几乎没有关联。AN、CVD 生物标志物与高甘油三酯腰围表型之间存在强烈的、与 BMI 无关的关联。
在这个年轻人群中，总 AN 和 HMW AN 与 CVD 危险因素之间存在明显的、与 BMI 无关的关联，而 LMW AN 则没有。这项对青少年的研究支持了这样一种观点，即 AN 亚组分可能具有不同的生物学作用。在明显健康的青少年中观察到这些关联表明，AN 及其亚组分在代谢综合征特征的发病机制中具有重要作用，并表明总 AN 或 HMW AN 作为 CV 风险的早期通用生物标志物的潜力值得进一步研究。
