Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands.
J Adolesc Health. 2010 Oct;47(4):346-51. doi: 10.1016/j.jadohealth.2010.04.008. Epub 2010 May 20.
The traditional approach for identifying subjects at risk from cardiovascular diseases (CVD) is to determine the extent of clustering of biological risk factors adjusted for lifestyle. Recently, markers of endothelial dysfunction and low grade inflammation, including high sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecules (sICAM), and soluble vascular adhesion molecules (sVCAM), have been included in the detection for high risk individuals. However, the relationship of these novel biomarkers with CVD risk in adolescents remains unclear. The purpose of this study, therefore, was to establish the association of hsCRP, sICAM, and sVCAM with CVD risk in an adolescent population.
Data from the Young Hearts 2000 cross-sectional cohort study, carried out in 1999-2001, were used. From a total of 2,017 male and female participants, 95 obese subjects were identified and matched according to age, sex, and cigarette smoking, with 95 overweight and 95 normal-weight adolescents. Clustered CVD risk was computed using a sum of Z-scores of biological risk factors. The relationship was described using multiple linear regression analyses.
hsCRP, sICAM, and sVCAM showed significant associations with CVD risk. hsCRP and sICAM had a positive relation with CVD risk, whereas sVCAM showed an inverse relationship. In this study, lifestyle factors showed no relation with CVD risk.
The results fit the hypothesized role of low grade inflammation and endothelial dysfunction in CVD risk in asymptomatic adolescents. The inverse relationship of VCAM, however, is hard to explain and indicates the complex mechanisms underlying CVD. Further research is needed to draw firm conclusions on the biomarkers used.
传统上，识别心血管疾病（CVD）高危人群的方法是确定经过生活方式调整后的生物风险因素聚集程度。最近，包括高敏 C 反应蛋白（hsCRP）、可溶性细胞间黏附分子（sICAM）和可溶性血管细胞黏附分子（sVCAM）在内的内皮功能障碍和低度炎症标志物已被纳入高危人群的检测中。然而，这些新型生物标志物与青少年 CVD 风险的关系尚不清楚。因此，本研究旨在确定 hsCRP、sICAM 和 sVCAM 与青少年 CVD 风险的相关性。
使用 1999-2001 年进行的“年轻心脏 2000”横断面队列研究的数据。在总共 2017 名男性和女性参与者中，确定了 95 名肥胖者，并根据年龄、性别和吸烟情况进行匹配，肥胖者与 95 名超重者和 95 名正常体重者相匹配。采用生物风险因素 Z 分数总和计算聚集 CVD 风险。使用多元线性回归分析描述相关性。
hsCRP、sICAM 和 sVCAM 与 CVD 风险呈显著相关性。hsCRP 和 sICAM 与 CVD 风险呈正相关，而 sVCAM 则呈负相关。在这项研究中，生活方式因素与 CVD 风险无关。
结果符合无症状青少年低度炎症和内皮功能障碍在 CVD 风险中作用的假设。然而，VCAM 的负相关关系很难解释，表明 CVD 背后的机制很复杂。需要进一步研究才能对所使用的生物标志物得出明确的结论。
