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1
RETRACTED: Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC).撤回：胰岛素样生长因子结合蛋白-7（IGFBP7）：一种有前途的肝细胞癌（HCC）基因治疗药物。
Mol Ther. 2013 Apr;21(4):758-66. doi: 10.1038/mt.2012.282. Epub 2013 Jan 15.
2
RETRACTED: Selective targeting of checkpoint kinase 1 in tumor cells with a novel potent oncolytic adenovirus.撤回：用一种新型强效溶瘤腺病毒对肿瘤细胞中的检查点激酶1进行选择性靶向作用
Mol Ther. 2006 May;13(5):928-937. doi: 10.1016/j.ymthe.2005.12.009. Epub 2006 Feb 3.
3
RETRACTED: SET1A Cooperates With CUDR to Promote Liver Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically.撤回：SET1A与CUDR协同作用，通过表观遗传促进肝癌生长和肝细胞样干细胞恶性转化。
Mol Ther. 2016 Feb;24(2):261-275. doi: 10.1038/mt.2015.208. Epub 2015 Nov 19.
4
RETRACTED: Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis.撤回：膜联蛋白 A7 调节线粒体凋亡中的 BAG4 和 BAG4 结合蛋白。
Biomed Pharmacother. 2015 Aug;74:30-4. doi: 10.1016/j.biopha.2015.06.005. Epub 2015 Jun 27.
5
Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma.胰岛素样生长因子结合蛋白-7 在肝细胞癌中作为一种潜在的肿瘤抑制因子发挥作用。
Clin Cancer Res. 2011 Nov 1;17(21):6693-701. doi: 10.1158/1078-0432.CCR-10-2774. Epub 2011 Sep 9.
6
RETRACTED: Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity.撤回：经基因工程改造以表达三种治疗因子的神经干细胞介导慢性期中枢神经系统自身免疫性疾病的恢复。
Mol Ther. 2016 Aug;24(8):1456-1469. doi: 10.1038/mt.2016.104. Epub 2016 May 16.
7
RETRACTED: Hepatocellular carcinoma cells-derived exosomal microRNA-378b enhances hepatocellular carcinoma angiogenesis.撤回：肝细胞癌细胞衍生的外泌体 microRNA-378b 增强肝癌血管生成。
Life Sci. 2021 May 15;273:119184. doi: 10.1016/j.lfs.2021.119184. Epub 2021 Feb 10.
8
RETRACTED: Physcion 8-O-β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1.撤回：大黄素 8-O-β-吡喃葡萄糖苷通过下调 PIM1 抑制肝癌肿瘤生长。
Biomed Pharmacother. 2017 Aug;92:451-458. doi: 10.1016/j.biopha.2017.05.110. Epub 2017 May 29.
9
RETRACTED: Protective autophagy induced by physcion suppresses hepatocellular carcinoma cell metastasis by inactivating the JAK2/STAT3 Axis.撤回声明：大黄素诱导的保护性自噬通过抑制 JAK2/STAT3 轴抑制肝癌细胞转移。
Life Sci. 2018 Dec 1;214:124-135. doi: 10.1016/j.lfs.2018.10.064. Epub 2018 Oct 30.
10
RETRACTED: Tumor cell-secreted exosomal miR-22-3p inhibits transgelin and induces vascular abnormalization to promote tumor budding.撤回：肿瘤细胞分泌的外泌体 miR-22-3p 抑制转胶蛋白并诱导血管异常化以促进肿瘤芽生。
Mol Ther. 2021 Jun 2;29(6):2151-2166. doi: 10.1016/j.ymthe.2021.02.009. Epub 2021 Feb 10.

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1
Broadening the paradigm of laminin α2-related muscular dystrophy: A case of partial merosin deficiency with compound heterozygous variants.拓宽层粘连蛋白α2相关型肌营养不良的范例：一例具有复合杂合变异的部分merosin缺乏症病例。
SAGE Open Med Case Rep. 2025 Aug 25;13:2050313X251366020. doi: 10.1177/2050313X251366020. eCollection 2025.
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IGFBP7 promotes gastric cancer by facilitating epithelial-mesenchymal transition of gastric cells.胰岛素样生长因子结合蛋白7通过促进胃细胞上皮-间质转化来促进胃癌发展。
Heliyon. 2024 May 9;10(10):e30986. doi: 10.1016/j.heliyon.2024.e30986. eCollection 2024 May 30.
3
Downregulation of Stemness Genes and Induction of Necrosis in Rat LA7 Cancer Stem Cells Induced Tumors Treated with Starved Fibroblasts Culture Supernatant.饥饿成纤维细胞培养上清液处理的大鼠LA7癌干细胞中干性基因的下调和坏死诱导可引发肿瘤。
Rep Biochem Mol Biol. 2021 Apr;10(1):105-118. doi: 10.52547/rbmb.10.1.105.
4
IGFBP7 acts as a negative regulator of RANKL-induced osteoclastogenesis and oestrogen deficiency-induced bone loss.IGFBP7 作为 RANKL 诱导的破骨细胞生成和雌激素缺乏诱导的骨丢失的负调节剂发挥作用。
Cell Prolif. 2020 Feb;53(2):e12752. doi: 10.1111/cpr.12752. Epub 2019 Dec 30.
5
Silence of IGFBP7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes.胰岛素样生长因子结合蛋白7的沉默可抑制高糖诱导的足细胞凋亡和上皮-间质转化。
Exp Ther Med. 2018 Aug;16(2):1095-1102. doi: 10.3892/etm.2018.6298. Epub 2018 Jun 13.
6
A Randomized Phase II Open-Label Multi-Institution Study of the Combination of Bevacizumab and Erlotinib Compared to Sorafenib in the First-Line Treatment of Patients with Advanced Hepatocellular Carcinoma.贝伐珠单抗联合厄洛替尼与索拉非尼一线治疗晚期肝细胞癌的随机 II 期开放标签多中心研究。
Oncology. 2018;94(6):329-339. doi: 10.1159/000485384. Epub 2018 May 2.
7
Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH.肾脏氨代谢基因多态性与24小时尿pH值相关。
Kidney Int Rep. 2017 Jun 21;2(6):1111-1121. doi: 10.1016/j.ekir.2017.06.009. eCollection 2017 Nov.
8
IGFBP7 Deletion Promotes Hepatocellular Carcinoma.胰岛素样生长因子结合蛋白7缺失促进肝细胞癌。
Cancer Res. 2017 Aug 1;77(15):4014-4025. doi: 10.1158/0008-5472.CAN-16-2885. Epub 2017 Jun 15.
9
Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma.SND1在肝细胞癌发生发展中的致癌作用
Cancer Res. 2017 Jun 15;77(12):3306-3316. doi: 10.1158/0008-5472.CAN-17-0298. Epub 2017 Apr 20.
10
Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells.被颠覆的血管生态位做出的分子检查点决定将惰性肿瘤细胞转化为化疗耐药的癌症干细胞。
Cancer Cell. 2017 Jan 9;31(1):110-126. doi: 10.1016/j.ccell.2016.11.010. Epub 2016 Dec 15.

本文引用的文献

1
Cancer statistics, 2012.癌症统计数据，2012 年。
CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29. doi: 10.3322/caac.20138. Epub 2012 Jan 4.
2
IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways.IGFBP7 通过诱导衰老和凋亡途径减少乳腺肿瘤生长。
Breast Cancer Res Treat. 2012 Jun;133(2):563-73. doi: 10.1007/s10549-011-1816-4. Epub 2011 Oct 14.
3
Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma.胰岛素样生长因子结合蛋白-7 在肝细胞癌中作为一种潜在的肿瘤抑制因子发挥作用。
Clin Cancer Res. 2011 Nov 1;17(21):6693-701. doi: 10.1158/1078-0432.CCR-10-2774. Epub 2011 Sep 9.
4
IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma.IGFBP7 下调与肝细胞癌的肿瘤进展和临床结局相关。
Int J Cancer. 2012 Jan 15;130(2):319-27. doi: 10.1002/ijc.25994. Epub 2011 Apr 13.
5
p53 and its mutants in tumor cell migration and invasion.p53 及其突变体在肿瘤细胞迁移和侵袭中的作用。
J Cell Biol. 2011 Jan 24;192(2):209-18. doi: 10.1083/jcb.201009059.
6
IGFBP7 is a p53 target gene inactivated in human lung cancer by DNA hypermethylation.IGFBP7 是一个 p53 靶基因，在人类肺癌中由于 DNA 超甲基化而失活。
Lung Cancer. 2011 Jul;73(1):38-44. doi: 10.1016/j.lungcan.2010.10.015. Epub 2010 Nov 20.
7
An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations.一种表达人腺病毒 5 和 3 纤维蛋白的腺病毒载体，用于靶向异质细胞群体。
Virology. 2010 Nov 25;407(2):196-205. doi: 10.1016/j.virol.2010.08.010. Epub 2010 Sep 9.
8
IGFBP7: an oncosuppressor gene in thyroid carcinogenesis.IGFBP7：甲状腺癌发生中的抑癌基因。
Oncogene. 2010 Jul 1;29(26):3835-44. doi: 10.1038/onc.2010.136. Epub 2010 May 3.
9
Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer.鉴定一种新型细胞死亡受体，介导 IGFBP-3 诱导的乳腺癌和前列腺癌的抗肿瘤作用。
J Biol Chem. 2010 Sep 24;285(39):30233-46. doi: 10.1074/jbc.M110.122226. Epub 2010 Mar 30.
10
Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines.IGFBP7 在治疗转移性黑色素瘤和其他癌症的小鼠模型和人细胞系中的疗效。
Mol Cancer Ther. 2009 Nov;8(11):3009-14. doi: 10.1158/1535-7163.MCT-09-0470. Epub 2009 Oct 27.

撤回：胰岛素样生长因子结合蛋白-7（IGFBP7）：一种有前途的肝细胞癌（HCC）基因治疗药物。

RETRACTED: Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC).

机构信息

Department of Pathology, Virginia Commonwealth University, School of Medicine, Richmond, Virginia 23298, USA.

出版信息

Mol Ther. 2013 Apr;21(4):758-66. doi: 10.1038/mt.2012.282. Epub 2013 Jan 15.

DOI:10.1038/mt.2012.282
PMID:23319057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3616543/
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the editor-in-chief. Similarities were found between images within this article. Image analysis performed by the editorial office confirmed findings of image duplication in Figures 1B, 4, and 8A. This reuse (and in part misrepresentation) of data without appropriate attribution represents a severe abuse of the scientific publishing system. No authors responded when contacted about the retraction.

摘要

本文已被撤回

请参阅爱思唯尔撤稿政策（http://www.elsevier.com/locate/withdrawalpolicy）。应主编要求，本文已被撤回。本文内的图像存在相似性。编辑部进行的图像分析证实了图 1B、4 和 8A 中存在图像重复的发现。这种没有适当归属的重复使用（部分是错误表示）数据的行为严重滥用了科学出版系统。在联系撤稿时，没有作者回应。