Department of Research, Social Insurance Institution, Turku, Finland.
J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):649-51. doi: 10.1097/MPG.0b013e318285e9d8.
We identified a total of 595 Finnish children born in 1994-2008 and diagnosed as having inflammatory bowel disease (IBD) by October 2010 from the National Reimbursement Register (based on certificates including the diagnostic criteria) to determine whether the presence of cow's milk allergy (CMA) or asthma is associated with the risk of contracting IBD (altogether 2380 matched controls). A diagnosis of CMA in infancy was associated with Crohn disease (odds ratio [OR] 1.92, confidence interval [CI] 1.09-3.36, P < 0.05) and ulcerative colitis (OR 1.71, CI 1.04-2.83, P < 0.05), but childhood asthma only with Crohn disease (OR 2.33, CI 1.41-3.86, P = 0.001). Thus, CMA in infants is a risk factor for contracting pediatric IBD and accordingly, asthma for Crohn disease.
我们从国家报销登记处（基于包括诊断标准的证书）中确定了 1994-2008 年期间出生的总共 595 名芬兰儿童，这些儿童在 2010 年 10 月前被诊断患有炎症性肠病（IBD），以确定是否存在牛奶过敏（CMA）或哮喘与患 IBD 的风险相关（共 2380 名匹配的对照）。婴儿期 CMA 的诊断与克罗恩病（比值比 [OR] 1.92，置信区间 [CI] 1.09-3.36，P < 0.05）和溃疡性结肠炎（OR 1.71，CI 1.04-2.83，P < 0.05）相关，但儿童哮喘仅与克罗恩病（OR 2.33，CI 1.41-3.86，P = 0.001）相关。因此，婴儿时期的 CMA 是儿童 IBD 的风险因素，相应地，哮喘是克罗恩病的风险因素。
