Department of Physiology, Faculty of Medicine, Centre for the Study of Pain, University of Toronto, Medical Sciences Building, King's College Circle, Toronto, Ontario, Canada. ; Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Exp Neurobiol. 2012 Dec;21(4):129-35. doi: 10.5607/en.2012.21.4.129. Epub 2012 Dec 26.
People experience the feeling of the missing body part long after it has been removed after amputation are known as phantom limb sensations. These sensations can be painful, sometimes becoming chronic and lasting for several years (or called phantom pain). Medical treatment for these individuals is limited. Recent neurobiological investigations of brain plasticity after amputation have revealed new insights into the changes in the brain that may cause phantom limb sensations and phantom pain. In this article, I review recent progresses of the cortical plasticity in the anterior cingulate cortex (ACC), a critical cortical area for pain sensation, and explore how they are related to abnormal sensory sensations such as phantom pain. An understanding of these alterations may guide future research into medical treatment for these disorders.
截肢后，人们在肢体缺失很久后仍能感受到缺失的身体部位，这种现象被称为幻肢感。这些感觉可能是痛苦的，有时会变成慢性的，并持续数年（也称为幻肢痛）。对于这些人，医学治疗是有限的。最近对截肢后大脑可塑性的神经生物学研究揭示了大脑变化的新见解，这些变化可能导致幻肢感和幻肢痛。在本文中，我回顾了前扣带皮层（ACC）皮质可塑性的最新进展，ACC 是疼痛感知的关键皮质区域，并探讨了它们与异常感觉（如幻肢痛）之间的关系。了解这些改变可能有助于指导未来对这些疾病的医学治疗的研究。
