Department of Morphometry of Endocrine Glands, Chair of Endocrinology, Medical University of Lodz, Poland.
Arch Med Sci. 2012 Dec 20;8(6):1059-64. doi: 10.5114/aoms.2012.32415. Epub 2012 Dec 19.
The aim of the study was to assess the influence of thyroid fine-needle aspiration biopsy (FNAB) on the size and ultrasound (US) features of the lesions and to examine whether the possible effects are persistent.
One hundred and fifty biopsied and 50 control thyroid nodules underwent two US examinations, 10-20 days and 8-10 weeks after the biopsy. The study took into account lesion volume alterations, both absolute and relative (with reference to its initial value), and the presence of US features of malignancy: hypoechogenicity, microcalcifications, internal blood flow, irregular or blurred margins and suspicious shape of the lesions. The analysis covered only those nodules which immediately after FNAB did not change their appearance owing to cyst fluid evacuation or intranodular hemorrhage.
The increase of the lesion volume was more frequent in the group of biopsied lesions than the control one (58.0% vs. 24.0%, p < 0.0001) with the highest increase of 61.5%. The mean change percentage, however, was determined below 5% and a tendency of the lesions to resume their initial volume was noticeable. Neither a persistent increase in nodule volume of above 50% nor significant changes in the presence of malignancy suggestive US features were observed after FNAB. None of the biopsied nodules developed any microcalcifications, irregular or blurred margins, internal blood flow, or suspicious shape.
Fine-needle aspiration biopsy does not cause permanent changes in the US image of biopsied lesions, provided that the sampling technique is appropriate and there are no significant changes observed during the biopsy.
本研究旨在评估甲状腺细针穿刺活检（FNAB）对病变大小和超声（US）特征的影响，并检查这些可能的影响是否持久。
150 个活检和 50 个对照甲状腺结节进行了两次 US 检查，分别在活检后 10-20 天和 8-10 周进行。研究考虑了病变体积的变化，包括绝对和相对变化（相对于其初始值），以及存在恶性肿瘤的 US 特征：低回声、微钙化、内部血流、不规则或模糊边界以及病变的可疑形状。分析仅涵盖那些由于囊液排出或结节内出血而在 FNAB 后立即没有改变外观的结节。
活检病变组的病变体积增加比对照组更常见（58.0%比 24.0%，p<0.0001），增加最高为 61.5%。然而，平均变化百分比确定低于 5%，并且可见病变恢复其初始体积的趋势。在 FNAB 后，未观察到结节体积持续增加超过 50%或存在提示恶性肿瘤的显著变化的 US 特征。活检后，无结节出现微钙化、不规则或模糊边界、内部血流或可疑形状。
只要采样技术适当，且在活检过程中未观察到明显变化，细针穿刺活检不会导致活检病变的 US 图像发生永久性变化。
