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稳定的无环脂肪族固体烯醇：合成、表征、X 射线结构分析和计算。

Stable acyclic aliphatic solid enols: synthesis, characterization, X-ray structure analysis and calculations.

机构信息

Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.

出版信息

Sci Rep. 2013;3:1058. doi: 10.1038/srep01058. Epub 2013 Jan 14.

DOI:10.1038/srep01058
PMID:23320139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3544012/
Abstract

A synthetic approach to stable enols was introduced and series of acyclic aliphatic solid enols were obtained and characterized. Relationship between the structure and the stability of these enols was discussed. Gaussian 09 calculations had been carried out to rationalize the stability of the enols. These enol structures were confirmed by (1)H NMR, (13)C NMR, MS, IR, partly by single crystal X-ray structure analysis and the protons exchange experiments. This work showed that very stable acyclic aliphatic enols can be synthesized efficiently without any purification.

摘要

引入了一种合成稳定烯醇的方法，并获得和表征了一系列的非循环脂肪族固体烯醇。讨论了这些烯醇的结构与稳定性之间的关系。通过高斯 09 计算对烯醇的稳定性进行了合理化解释。这些烯醇结构通过 (1)H NMR、(13)C NMR、MS、IR 得到了证实，部分通过单晶 X 射线结构分析和质子交换实验得到了证实。这项工作表明，可以有效地合成非常稳定的非循环脂肪族烯醇，而无需任何纯化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/37207b3ea03d/srep01058-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/a6365aa67cf9/srep01058-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/90f46e03982c/srep01058-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/5cc4315d63bc/srep01058-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/14af36e5ba05/srep01058-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/4984fb3a1274/srep01058-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/e3f04687e6b1/srep01058-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/36098533989b/srep01058-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/c88ff6c97ed1/srep01058-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/37207b3ea03d/srep01058-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/a6365aa67cf9/srep01058-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/90f46e03982c/srep01058-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/5cc4315d63bc/srep01058-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/14af36e5ba05/srep01058-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/4984fb3a1274/srep01058-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/e3f04687e6b1/srep01058-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/36098533989b/srep01058-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/c88ff6c97ed1/srep01058-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f79/3544012/37207b3ea03d/srep01058-f9.jpg

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9
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