Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA.
J Thorac Cardiovasc Surg. 2013 Feb;145(2):364-72. doi: 10.1016/j.jtcvs.2012.10.051.
The present study evaluated the evolving trends and outcomes of patients undergoing isolated reoperative coronary artery bypass grafting at Society of Thoracic Surgeons Adult Cardiac Surgery Database-participating institutions.
From 2000 to 2009, 72,431 patients underwent isolated reoperative coronary artery bypass grafting and 1,497,254 patients underwent isolated primary coronary artery bypass grafting at Society of Thoracic Surgeons-participating institutions. The demographics, operative characteristics, and risk-adjusted postoperative outcomes were assessed and compared during the study period.
As a percentage of overall coronary artery bypass grafting volume, reoperative coronary artery bypass grafting decreased from 6.0% (8820/137,267) in 2000 to 3.4% (5734/160,997) in 2009. The unadjusted operative mortality declined from 6.1% (542/8820) in 2000 to 4.6% (261/5734) in 2009 (P < .05). Patients now more frequently present with left main disease (35.1% vs 25.7%; P < .05), myocardial infarction (60.9% vs 55.9%; P < .001), and heart failure (18.4% vs 14.2%; P < .001). Patients also now present more frequently for urgent or emergent surgery (51.6% vs 39%; P < .001) and after previous percutaneous coronary intervention (51% vs 35%; P < .001). They also have a greater incidence of other comorbidities such as increased weight (88 vs 84 kg; P < .001), diabetes (42.5% vs 31.7%; P < .001), hypertension (90.9% vs 73.4%; P < .001), hypercholesterolemia (90.9% vs 73.4%; P < .001), renal failure (2.2% vs 0.7%; P < .001), and cerebrovascular disease (12.4% vs 8.5%; P < .001). Risk-adjusted mortality decreased from 6.0% to 4.6%, a relative risk reduction of 23.7% (P < .001). Risk-adjusted postoperative stroke decreased from 1.9% to 1.6% (P < .001).
Surgical coronary revascularization has evolved during the past decade, with reoperative coronary artery bypass grafting now uncommonly performed in contemporary practice. Despite treating patients with more complex coronary artery disease and greater medical comorbidities, significant improvements have occurred in operative morbidity and mortality in this challenging population.
本研究评估了在胸外科医师学会(STS)成人心脏手术数据库参与机构中,接受单纯再次冠状动脉旁路移植术(reoperative coronary artery bypass grafting,re-CABG)的患者的演变趋势和结局。
2000 年至 2009 年,STS 参与机构共进行了 72431 例单纯再次 CABG 和 1497254 例单纯初次 CABG。在此期间评估并比较了患者的人口统计学、手术特征和风险调整后术后结局。
再次 CABG 占冠状动脉旁路移植术总量的比例从 2000 年的 6.0%(8820/137267)下降到 2009 年的 3.4%(5734/160997)。未调整的手术死亡率从 2000 年的 6.1%(542/8820)降至 2009 年的 4.6%(261/5734)(P<0.05)。现在患者更频繁地患有左主干疾病(35.1%比 25.7%;P<0.05)、心肌梗死(60.9%比 55.9%;P<0.001)和心力衰竭(18.4%比 14.2%;P<0.001)。现在患者也更频繁地接受紧急或紧急手术(51.6%比 39%;P<0.001)和经皮冠状动脉介入治疗后(51%比 35%;P<0.001)。他们还有其他合并症的发病率更高,例如体重增加(88 公斤比 84 公斤;P<0.001)、糖尿病(42.5%比 31.7%;P<0.001)、高血压(90.9%比 73.4%;P<0.001)、高胆固醇血症(90.9%比 73.4%;P<0.001)、肾功能衰竭(2.2%比 0.7%;P<0.001)和脑血管疾病(12.4%比 8.5%;P<0.001)。风险调整后的死亡率从 6.0%降至 4.6%,相对风险降低 23.7%(P<0.001)。风险调整后的术后卒中从 1.9%降至 1.6%(P<0.001)。
在过去十年中,冠状动脉旁路移植术得到了发展,在当代实践中再次 CABG 已不常见。尽管接受手术的患者患有更复杂的冠状动脉疾病和更多的合并症,但在这一具有挑战性的人群中,手术发病率和死亡率显著改善。