Vítovec J, Koudela B
Institute of Parasitology, Czechoslovak Academy of Sciences, Ceské Budĕjovice.
Folia Parasitol (Praha). 1990;37(1):21-33.
The pathogenicity of the coccidium Isospora suis was studied in 42 conventional and 26 gnotobiotic piglets at 1-13 days post infection (DPI). The prepatent period of the coccidium I. suis was 4.5-5 days. Only in one experiment in conventional piglets the prepatent period of 3.5 days was recorded. At least 9 days pathogenesis of I. suis was recorded during which double alteration of the small intestine occurred. The first alteration was found at 3-4 DPI. The second phase of alterative changes was observed at 8-9 DPI. In comparison with gnotobiotic piglets in conventional piglets clinical signs and pathological changes used to appear one day sooner but reparation and regeneration of alterative changes was quicker. In the first phase of the infection (3-7 or 8 DPI) the heaviest pathological changes were in the posterior jejunum. In the second phase of the infection (8 or 9-12 DPI) the heaviest changes were in the middle jejunum. In short period repeated lesions of mucosal barrier of the small intestine multiply the pathogenicity of I. suis and rank I. suis in front place among other enteropathogens of nursing piglets.
在42头常规饲养仔猪和26头无菌仔猪中研究了猪等孢球虫的致病性，感染时间为感染后1至13天（DPI）。猪等孢球虫的潜隐期为4.5至5天。仅在一项针对常规饲养仔猪的实验中记录到潜隐期为3.5天。记录到猪等孢球虫至少9天的致病过程，在此期间小肠出现了双重病变。第一次病变出现在感染后3至4天。第二次病变变化阶段在感染后8至9天观察到。与无菌仔猪相比，常规饲养仔猪的临床症状和病理变化通常提前一天出现，但病变的修复和再生更快。在感染的第一阶段（感染后3至7或8天），最严重的病理变化出现在空肠后部。在感染的第二阶段（感染后8或9至12天），最严重的变化出现在空肠中部。在短时间内小肠黏膜屏障的反复损伤会增加猪等孢球虫的致病性，并使猪等孢球虫在哺乳仔猪的其他肠道病原体中名列前茅。
