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Working mechanism underlying the reduction of the behavioral and accumbal dopamine response to cocaine by α-1-adrenoceptor antagonists.α-1肾上腺素能受体拮抗剂降低对可卡因的行为和伏隔核多巴胺反应的潜在作用机制。
Neuropsychopharmacology. 2013 Feb;38(3):540-1. doi: 10.1038/npp.2012.209.
2
Simultaneous activation of the α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats.伏隔核中α1A-、α1B-和α1D-肾上腺素能受体亚型的同时激活会降低自由活动大鼠伏隔核中的多巴胺流出量。
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The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.伏隔核中的 α₁-肾上腺素受体（而非 α₂-肾上腺素受体）对自由活动大鼠伏隔核内去甲肾上腺素和多巴胺的外排起到抑制作用。
Eur J Pharmacol. 2012 Aug 5;688(1-3):35-41. doi: 10.1016/j.ejphar.2012.05.005. Epub 2012 May 19.
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Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways.5-羟色胺 2B 受体阻断在大鼠中缝背核抑制可卡因诱导的过度活动，通过对中皮质和中伏隔核多巴胺通路的相反控制。
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Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens.对可卡因反应不同的大鼠，其伏隔核多巴胺储存能力也不同。
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Psychostimulant sensitization: differential changes in accumbal shell and core dopamine.精神兴奋剂敏化：伏隔核壳部和核心多巴胺的差异变化。
Eur J Pharmacol. 2000 Jan 24;388(1):69-76. doi: 10.1016/s0014-2999(99)00824-9.
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The 5-HT1A receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens.5-羟色胺1A受体调节可卡因对伏隔核细胞外5-羟色胺和多巴胺水平的影响。
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Synergistic, but not separate, stimulation of accumbal β1- and β2-adrenoceptors alters the accumbal dopamine efflux in freely moving rats.β1-和β2-肾上腺素受体在伏隔核中的协同而非独立刺激改变了自由活动大鼠伏隔核多巴胺的外流。
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The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.非肽类δ阿片受体激动剂TAN-67通过一种涉及谷氨酸和自由基的机制增强自由活动大鼠伏隔核中的多巴胺外流。
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Differences in receptor system participation between nicotine- and cocaine-induced dopamine overflow in nucleus accumbens.伏隔核中尼古丁和可卡因诱导的多巴胺释放所涉及的受体系统差异。
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引用本文的文献

1
Assessing attention and impulsivity in the variable stimulus duration and variable intertrial interval rodent continuous performance test schedules using noradrenaline receptor antagonists in female C57BL/6JRj mice.使用去甲肾上腺素受体拮抗剂评估雌性 C57BL/6JRj 小鼠在可变刺激持续时间和可变试验间隔棒状连续表现测试方案中的注意力和冲动性。
Psychopharmacology (Berl). 2023 Aug;240(8):1629-1650. doi: 10.1007/s00213-023-06385-9. Epub 2023 Jun 17.
2
Noradrenaline-induced release of newly-synthesized accumbal dopamine: differential role of alpha- and beta-adrenoceptors.去甲肾上腺素诱导新合成的伏隔核多巴胺释放：α-和β-肾上腺素能受体的不同作用
Front Cell Neurosci. 2014 Aug 21;8:243. doi: 10.3389/fncel.2014.00243. eCollection 2014.

本文引用的文献

1
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.伏隔核中的 α₁-肾上腺素受体（而非 α₂-肾上腺素受体）对自由活动大鼠伏隔核内去甲肾上腺素和多巴胺的外排起到抑制作用。
Eur J Pharmacol. 2012 Aug 5;688(1-3):35-41. doi: 10.1016/j.ejphar.2012.05.005. Epub 2012 May 19.
2
α-1 Adrenergic receptors are localized on presynaptic elements in the nucleus accumbens and regulate mesolimbic dopamine transmission.α-1 肾上腺素能受体位于伏隔核的突触前成分上，并调节中脑边缘多巴胺传递。
Neuropsychopharmacology. 2012 Aug;37(9):2161-72. doi: 10.1038/npp.2012.68. Epub 2012 May 16.
3
Mesolimbic alpha-, but not beta-adrenoceptors control the accumbal release of dopamine that is derived from reserpine-sensitive storage vesicles.中脑边缘系统的α-肾上腺素能受体而非β-肾上腺素能受体，控制着源自利血平敏感储存囊泡的伏隔核多巴胺释放。
Neuroscience. 2009 Sep 15;162(4):1163-73. doi: 10.1016/j.neuroscience.2009.05.034. Epub 2009 May 21.
4
Twenty years of dopamine research: individual differences in the response of accumbal dopamine to environmental and pharmacological challenges.二十年多巴胺研究：伏隔核多巴胺对环境及药理学刺激反应的个体差异
Eur J Pharmacol. 2008 May 13;585(2-3):228-44. doi: 10.1016/j.ejphar.2008.02.084. Epub 2008 Mar 15.
5
Role of alpha adrenoceptors in the nucleus accumbens in the control of accumbal noradrenaline efflux: a microdialysis study with freely moving rats.伏隔核中α肾上腺素能受体在控制伏隔核去甲肾上腺素外流中的作用：对自由活动大鼠的微透析研究
J Neural Transm (Vienna). 2007 Sep;114(9):1135-42. doi: 10.1007/s00702-007-0745-1. Epub 2007 May 29.
6
High and low responders to novelty: effects of adrenergic agents on the regulation of accumbal dopamine under challenged and non-challenged conditions.对新异刺激反应高和低的个体：肾上腺素能药物在应激和非应激条件下对伏隔核多巴胺调节的影响
Neuroscience. 2000;99(1):55-64. doi: 10.1016/s0306-4522(00)00139-1.

Working mechanism underlying the reduction of the behavioral and accumbal dopamine response to cocaine by α-1-adrenoceptor antagonists.

作者信息

Verheij Michel M M, Saigusa Tadashi, Koshikawa Noriaki, Cools Alexander R

出版信息

Neuropsychopharmacology. 2013 Feb;38(3):540-1. doi: 10.1038/npp.2012.209.

DOI:10.1038/npp.2012.209
PMID:23322161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3547201/
Abstract
摘要