Robienski J, Hoppe N
CELLS - Centre for Ethics and Law in the Life Sciences, Leibniz Universität Hannover, Am Klagesmarkt 14-17, 30159, Hannover, Deutschland.
Pathologe. 2013 Feb;34(1):9-15. doi: 10.1007/s00292-012-1703-8.
The increase in density of information available in relation to patients and research participants, in particular in the context of genetic diagnostics and analysis, results in an increased potential for uncovering details which were unexpected but are of particular significance for the patient. Deciding how this information is dealt with and who is entitled to receive this information, is a medicolegal and ethical balancing act. Incidental findings and the challenges posed by the advent of personalised medicine are but two areas which increasingly impact medical disciplines that do not conventionally work directly with patients. Both areas raise questions of what is legally required and morally necessary. The authors briefly sketch these two areas and the medicolegal and ethical implications for diagnostics and research in pathology.
与患者和研究参与者相关的可用信息密度增加,特别是在基因诊断和分析的背景下,导致发现意外但对患者具有特殊意义的细节的可能性增加。决定如何处理这些信息以及谁有权接收这些信息,是一项法医学和伦理学的平衡行为。偶发发现以及个性化医疗的出现所带来的挑战只是两个越来越影响传统上不直接与患者打交道的医学学科的领域。这两个领域都引发了关于法律要求和道德必要性的问题。作者简要概述了这两个领域以及病理学诊断和研究中的法医学和伦理学含义。