Smith Bryce D, Jewett Amy, Drobeniuc Jan, Kamili Saleem
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Antivir Ther. 2012;17(7 Pt B):1409-13. doi: 10.3851/IMP2470. Epub 2012 Dec 7.
Approximately 4.1 million Americans have been infected with HCV and 45-85% of chronically infected persons are unaware of their status. Rapid anti-HCV assays can assist and expedite the identification of those unaware of their infection. Performance characteristics of pre-market rapid anti-HCV assays (Chembio, MedMira and OraSure) have been evaluated. Their sensitivity (78.9-99.3%) and specificity (80-100%) varied. Future investigations could include evaluation of rapid anti-HCV tests in persons who are coinfected with HCV and HIV, and development of rapid HCV-antigen tests and nucleic acid tests.
约410万美国人感染了丙型肝炎病毒，45%至85%的慢性感染者并不知道自己的感染状况。快速丙型肝炎病毒抗体检测可有助于并加快识别那些不知自己已被感染的人。已对上市前快速丙型肝炎病毒抗体检测（Chembio、MedMira和OraSure）的性能特征进行了评估。其灵敏度（78.9%至99.3%）和特异性（80%至100%）各不相同。未来的研究可包括评估丙型肝炎病毒和人类免疫缺陷病毒合并感染者的快速丙型肝炎病毒抗体检测，以及开发快速丙型肝炎病毒抗原检测和核酸检测。
