• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma after dapsone-induced hypersensitivity syndrome.

作者信息

Rim Min Young, Hong Junshik, Yo Inku, Park Hyeonsu, Chung Dong Hae, Ahn Jeong Yeal, Park Sanghui, Park Jinny, Kim Yun Soo, Lee Jae Hoon

机构信息

Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.

出版信息

Korean J Pathol. 2012 Dec;46(6):606-10. doi: 10.4132/KoreanJPathol.2012.46.6.606. Epub 2012 Dec 26.

DOI:10.4132/KoreanJPathol.2012.46.6.606
PMID:23323115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3540342/
Abstract

A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively, and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly. Excisional biopsy of a cervical lymph node showed effacement of the normal architecture with atypical lymphoid hyperplasia and proliferation of high endothelial venules compatible with angioimmunoblastic T-cell lymphoma. However, it was assumed that the cervical lymphadenopathy was a clinical manifestation of a systemic hypersensitivity reaction because her clinical course was reminiscent of dapsone-induced hypersensitivity syndrome. A liver biopsy revealed drug-induced hepatitis with no evidence of lymphomatous involvement. Intravenous glucocorticoid was immediately initiated and her symptoms and clinical disease dramatically improved. The authors present an unusual case of cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma as an adverse reaction to dapsone.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/a6976f6237b8/kjpathol-46-606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/4a797706dec2/kjpathol-46-606-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/f57ac81c5065/kjpathol-46-606-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/f745b3d9d190/kjpathol-46-606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/2e7bd813dfe4/kjpathol-46-606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/a6976f6237b8/kjpathol-46-606-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/4a797706dec2/kjpathol-46-606-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/f57ac81c5065/kjpathol-46-606-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/f745b3d9d190/kjpathol-46-606-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/2e7bd813dfe4/kjpathol-46-606-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42a8/3540342/a6976f6237b8/kjpathol-46-606-g005.jpg

相似文献

1
Cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma after dapsone-induced hypersensitivity syndrome.
Korean J Pathol. 2012 Dec;46(6):606-10. doi: 10.4132/KoreanJPathol.2012.46.6.606. Epub 2012 Dec 26.
2
[A Case of Angioimmunoblastic T-cell Lymphoma (AITL)].[血管免疫母细胞性T细胞淋巴瘤（AITL）一例]
J UOEH. 2022;44(3):293-299. doi: 10.7888/juoeh.44.293.
3
[Angioimmunoblastic T-cell lymphoma with fever, arthritis and skin pigmentation: A case report].[伴发热、关节炎及皮肤色素沉着的血管免疫母细胞性T细胞淋巴瘤：1例报告]
Beijing Da Xue Xue Bao Yi Xue Ban. 2020 Dec 18;52(6):1150-1152. doi: 10.19723/j.issn.1671-167X.2020.06.028.
4
Dapsone hypersensitivity syndrome with circulating 190-kDa and 230-kDa autoantibodies.二氨苯砜超敏反应综合征伴循环 190kDa 和 230kDa 自身抗体。
Clin Exp Dermatol. 2009 Dec;34(8):e798-801. doi: 10.1111/j.1365-2230.2009.03527.x. Epub 2009 Sep 22.
5
Angioimmunoblastic T-cell Lymphoma: An Unusual Case in an Octogenarian.血管免疫母细胞性T细胞淋巴瘤：一位八旬老人的罕见病例
Cureus. 2020 Feb 11;12(2):e6956. doi: 10.7759/cureus.6956.
6
Lymph node pathology in patients with a clinical diagnosis of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD): an analysis of 37 cases.
Asian Pac J Allergy Immunol. 1997 Mar;15(1):15-20.
7
Dapsone induced cholangitis as a part of dapsone syndrome: a case report.氨苯砜诱发胆管炎作为氨苯砜综合征的一部分：病例报告
BMC Gastroenterol. 2003 Aug 11;3:21. doi: 10.1186/1471-230X-3-21.
8
A Case of Generalized, Superinfected Dermatitis and Inguinal Mycobacterium Lymphadenitis - TB or not TB?一例全身性、合并感染性皮炎及腹股沟淋巴结结核——是结核吗？
Acta Dermatovenerol Croat. 2018 Oct;26(3):270-272.
9
[Spontaneous Splenic Rupture with Angioimmunoblastic T-Cell Lymphoma Successfully Treated Using Transcatheter Arterial Embolization].[经导管动脉栓塞术成功治疗血管免疫母细胞性T细胞淋巴瘤伴自发性脾破裂]
Gan To Kagaku Ryoho. 2020 Jul;47(7):1097-1099.
10
A Case of Angioimmunoblastic T-cell Lymphoma Hidden in Plain Sight: A Delay in Diagnosis and Management.一例隐匿于眼前的血管免疫母细胞性T细胞淋巴瘤：诊断与治疗延误
J Med Cases. 2022 Mar;13(3):109-114. doi: 10.14740/jmc3890. Epub 2022 Mar 5.

引用本文的文献

1
Non-leprosy related dapsone hypersensitivity syndrome: A case report and literature review.非麻风相关的氨苯砜超敏反应综合征：一例病例报告及文献综述
Medicine (Baltimore). 2025 Jul 4;104(27):e43073. doi: 10.1097/MD.0000000000043073.
2
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review.抗菌抗生素引起的伴嗜酸性粒细胞增多和全身症状（DRESS）综合征：文献综述。
Eur J Clin Pharmacol. 2021 Mar;77(3):275-289. doi: 10.1007/s00228-020-03005-9. Epub 2020 Oct 6.
3
Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma.

本文引用的文献

1
Angioimmunoblastic T-Cell lymphoma: a critical analysis of clinical, morphologic and immunophenotypic features.
Indian J Pathol Microbiol. 2010 Oct-Dec;53(4):640-5. doi: 10.4103/0377-4929.72010.
2
Valsartan-induced drug eruption followed by CD30+ pseudolymphomatous eruption.缬沙坦诱发的药疹，随后出现CD30+假性淋巴瘤样皮疹。
Acta Derm Venereol. 2010 Sep;90(5):521-2. doi: 10.2340/00015555-0695.
3
Complete atrioventricular block associated with dapsone therapy: a rare complication of dapsone-induced hypersensitivity syndrome.与氨苯砜治疗相关的完全性房室传导阻滞：氨苯砜诱导的超敏反应综合征的一种罕见并发症。
药物性超敏反应综合征：一种淋巴瘤的临床、影像学及组织学模拟表现
Case Rep Hematol. 2018 Oct 21;2018:7037352. doi: 10.1155/2018/7037352. eCollection 2018.
4
In vitro testing for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology.用于诊断特异质性药物不良反应的体外试验：对病理生理学的意义
Br J Clin Pharmacol. 2015 Oct;80(4):889-900. doi: 10.1111/bcp.12505. Epub 2015 Jun 1.
J Clin Pharm Ther. 2009 Aug;34(4):489-92. doi: 10.1111/j.1365-2710.2008.00991.x.
4
Pseudolymphoma as adverse reaction to tamoxifen.
J Eur Acad Dermatol Venereol. 2008 Aug;22(8):1004-5. doi: 10.1111/j.1468-3083.2007.02474.x. Epub 2008 Mar 22.
5
CD30-positive T-cell pseudolymphoma induced by amlodipine.
J Eur Acad Dermatol Venereol. 2008 Dec;22(12):1522-4. doi: 10.1111/j.1468-3083.2008.02671.x. Epub 2008 Apr 29.
6
The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.再谈氨苯砜超敏反应综合征：一种具有显著肝肺表现的潜在致命性多系统疾病。
J Occup Med Toxicol. 2006 Jun 6;1:9. doi: 10.1186/1745-6673-1-9.
7
Drug-induced and iatrogenic infiltrative lung disease.药物性和医源性浸润性肺病。
Clin Chest Med. 2004 Sep;25(3):479-519, vi. doi: 10.1016/j.ccm.2004.05.006.
8
Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas.抗惊厥药物所致淋巴结病，临床病理表现酷似恶性淋巴瘤。
Cancer. 1959 Jan-Feb;12(1):164-82. doi: 10.1002/1097-0142(195901/02)12:1<164::aid-cncr2820120122>3.0.co;2-y.
9
Dapsone induced cholangitis as a part of dapsone syndrome: a case report.氨苯砜诱发胆管炎作为氨苯砜综合征的一部分：病例报告
BMC Gastroenterol. 2003 Aug 11;3:21. doi: 10.1186/1471-230X-3-21.
10
Reactive metabolites and adverse drug reactions: clinical considerations.反应性代谢产物与药物不良反应：临床考量
Clin Rev Allergy Immunol. 2003 Jun;24(3):229-38. doi: 10.1385/CRIAI:24:3:229.