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Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients.

作者信息

Deenen Maarten J, Cats Annemieke, Beijnen Jos H, Schellens Jan H M

机构信息

Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, and Department of Clinical Pharmacy, Rijnstate Hospital, Wagnerlaan 55, 6815 AD Arnhem, The Netherlands.

出版信息

Ther Adv Med Oncol. 2013 Jan;5(1):91-2. doi: 10.1177/1758834012464806.

DOI:10.1177/1758834012464806
PMID:23323150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3539277/
Abstract
摘要

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1
Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients.标准剂量替加氟-尿嘧啶（UFT）对于部分二氢嘧啶脱氢酶缺乏的患者而言并非安全的替代药物。
Ther Adv Med Oncol. 2013 Jan;5(1):91-2. doi: 10.1177/1758834012464806.
2
Tegafur-uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle.替加氟-尿嘧啶是治疗部分二氢嘧啶脱氢酶缺乏的结直肠癌患者的安全替代药物：原理验证。
Ther Adv Med Oncol. 2012 Jul;4(4):167-72. doi: 10.1177/1758834012441049.
3
Predictive value of dihydropyrimidine dehydrogenase expression in tumor tissue, regarding the efficacy of postoperatively administered UFT (Tegafur + Uracil) in patients with p-stage I nonsmall-cell lung cancer.二氢嘧啶脱氢酶在肿瘤组织中的表达对Ⅰ期非小细胞肺癌患者术后给予优福定（替加氟+尿嘧啶）疗效的预测价值。
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4
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil.5-乙炔基尿嘧啶（776C85）：对5-氟尿嘧啶前体药物替加氟的抗肿瘤活性和药代动力学的影响。
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Tegafur-uracil (UFT) in lower doses is safe for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle.低剂量替加氟-尿嘧啶（UFT）对部分二氢嘧啶脱氢酶缺乏的结直肠癌患者治疗是安全的：一项原理验证。
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Phase II study of preoperative radiation plus concurrent daily tegafur-uracil (UFT) with leucovorin for locally advanced rectal cancer.术前放疗联合卡培他滨（UFT）和亚叶酸治疗局部进展期直肠癌的 II 期研究。
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引用本文的文献

1
Tegafur-uracil (UFT) in lower doses is safe for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle.低剂量替加氟-尿嘧啶（UFT）对部分二氢嘧啶脱氢酶缺乏的结直肠癌患者治疗是安全的：一项原理验证。
Ther Adv Med Oncol. 2013 Jan;5(1):93-4. doi: 10.1177/1758834012469430.

本文引用的文献

1
Tegafur-uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle.替加氟-尿嘧啶是治疗部分二氢嘧啶脱氢酶缺乏的结直肠癌患者的安全替代药物：原理验证。
Ther Adv Med Oncol. 2012 Jul;4(4):167-72. doi: 10.1177/1758834012441049.
2
Standard-dose tegafur combined with uracil is not safe treatment after severe toxicity from 5-fluorouracil or capecitabine.在出现5-氟尿嘧啶或卡培他滨严重毒性反应后，标准剂量替加氟联合尿嘧啶并非安全的治疗方法。
Ann Intern Med. 2010 Dec 7;153(11):767-8. doi: 10.7326/0003-4819-153-11-201012070-00023.
3
Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.全胃切除术后口服S-1后S-1成分、5-氟尿嘧啶、二氢氟尿嘧啶和α-氟-β-丙氨酸的替代药代动力学
Cancer Sci. 2007 Oct;98(10):1604-8. doi: 10.1111/j.1349-7006.2007.00573.x. Epub 2007 Aug 7.
4
The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.尿嘧啶呼气试验在二氢嘧啶脱氢酶活性评估中的应用：呼出的13CO2与血浆[2-13C]二氢尿嘧啶之间的药代动力学关系
Clin Cancer Res. 2006 Jan 15;12(2):549-55. doi: 10.1158/1078-0432.CCR-05-2020.
5
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.一种新型抗病毒药物索立夫定与口服5-氟尿嘧啶前体药物相互作用导致18例患者死亡的可能机制。
J Pharmacol Exp Ther. 1998 Nov;287(2):791-9.
6
Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2'-tetrahydrofuryl)-5-fluorouracil.接受持续5-氟尿嘧啶输注的患者与口服尿嘧啶加N1-(2'-四氢呋喃基)-5-氟尿嘧啶患者的5-氟尿嘧啶药代动力学比较。
Clin Cancer Res. 1998 Sep;4(9):2085-8.
7
Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.源自抗病毒药物索立夫定的（E）-5-（2-溴乙烯基）尿嘧啶对人二氢嘧啶脱氢酶的自杀性失活作用
Cancer Lett. 1998 Jan 9;122(1-2):107-13. doi: 10.1016/s0304-3835(97)00377-7.
8
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.一种新型口服5-氟尿嘧啶衍生物（S-1）的研发，该衍生物通过两种生化调节剂增强5-氟尿嘧啶的肿瘤选择性细胞毒性。
Anticancer Drugs. 1996 Jul;7(5):548-57. doi: 10.1097/00001813-199607000-00010.
9
Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats.1 M替加氟-0.4 M 5-氯-2,4-二羟基吡啶-1 M奥替拉西钾（S-1）对原位植入裸鼠的人结肠癌的抗肿瘤活性。
Cancer Res. 1996 Jun 1;56(11):2602-6.