Volchegorskiĭ I A, Pravdin E V, Uzlova T V
Eksp Klin Farmakol. 2012;75(11):22-7.
Short-term, prospective placebo-controlled simple blind randomized study of the effects of 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin, mexidol) on the affective status of females with recrudescence of the inflammatory diseases of uterus and its appendages (IDUA) in comparison to changes of systemic inflammatory response (SIR) markers level in the blood has been conducted. It is established that the inclusion of emoxipin, reamberin and mexidol in complex treatment of IDUA recrudescence reduce depression, anxiety and SIR laboratory signs. Mexidol being both 3-oxypyridine and succinic acid derivative showed the best influence on the dynamics of affective disorders and SIR changes.
开展了一项短期、前瞻性、安慰剂对照、单盲随机研究,以比较3-羟基吡啶和琥珀酸衍生物(依莫昔芬、雷氨蝶呤、美西多宁)对患有子宫及其附件炎症性疾病复发(IDUA)的女性情感状态的影响,并与血液中全身炎症反应(SIR)标志物水平的变化进行对比。结果表明,在IDUA复发的综合治疗中加入依莫昔芬、雷氨蝶呤和美西多宁可减轻抑郁、焦虑和SIR实验室指标。美西多宁作为3-羟基吡啶和琥珀酸衍生物,对情感障碍动态变化和SIR改变的影响最为显著。