Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, PR China.
Immunol Invest. 2013;42(2):91-105. doi: 10.3109/08820139.2012.724752.
Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) -1722T/C polymorphism has been identified as a susceptibile gene for systemic lupus erythematosus (SLE), but studies are inconsistent. To better assess the association between CTLA-4 -1722T/C polymorphism and SLE, a meta-analysis was performed, including 10 studies, total of 1 387 patients and 1 617 controls. Overall, the CTLA-4 -1722T/C polymorphism was significantly associated with SLE susceptibility (T VS C: OR = 1.17, 95% CI = 0.86-1.60, P = 0.304; T/T VS C/C: OR = 1.92, 95% CI = 1.09-3.39, P = 0.024; T/C VS C/C: OR = 1.50, 95% CI = 0.91-2.49, P = 0.114; T/T VS T/C: OR = 1.29, 95% CI = 0.95-1.75, P = 0.107). When stratified by ethnicity, the CTLA-4 -1722T/C polymorphism was associated with SLE only in Asians (T VS C: OR = 1.47, 95% CI = 1.10-1.96, P = 0.010; T/T VS C/C: OR = 2.09, 95% CI = 1.13-3.85, P = 0.018; T/C VS C/C: OR = 1.53, 95% CI = 0.87-2.69, P = 0.141; T/T VS T/C: OR = 1.42, 95% CI = 0.97-2.09, P = 0.070). In summary, the CTLA-4 -1722T/C polymorphism confers to SLE risk, especially in Asians.
细胞毒性 T 淋巴细胞相关抗原 4（CTLA-4）-1722T/C 多态性已被确定为系统性红斑狼疮（SLE）的易感基因，但研究结果并不一致。为了更好地评估 CTLA-4-1722T/C 多态性与 SLE 之间的关联，进行了一项荟萃分析，共纳入 10 项研究，总计 1387 例患者和 1617 例对照。总的来说，CTLA-4-1722T/C 多态性与 SLE 易感性显著相关（T 等位基因比 C 等位基因：OR=1.17，95%CI=0.86-1.60，P=0.304；T/T 比 C/C：OR=1.92，95%CI=1.09-3.39，P=0.024；T/C 比 C/C：OR=1.50，95%CI=0.91-2.49，P=0.114；T/T 比 T/C：OR=1.29，95%CI=0.95-1.75，P=0.107）。按种族分层后，仅在亚洲人群中 CTLA-4-1722T/C 多态性与 SLE 相关（T 等位基因比 C 等位基因：OR=1.47，95%CI=1.10-1.96，P=0.010；T/T 比 C/C：OR=2.09，95%CI=1.13-3.85，P=0.018；T/C 比 C/C：OR=1.53，95%CI=0.87-2.69，P=0.141；T/T 比 T/C：OR=1.42，95%CI=0.97-2.09，P=0.070）。综上所述，CTLA-4-1722T/C 多态性与 SLE 风险相关，尤其是在亚洲人群中。
