Skanjeti A, Angusti T, Iudicello M, Dazzara F, Delgado Yabar G M, Trevisiol E, Podio V
Nuclear Medicine Unit, San Luigi Gonzaga Hospital, University of Turin, Reg. Gonzole 10, 10043, Orbassano, Italy; Medical Science Department, University A. Avogadro, Novara, Italy.
J Neuroimaging. 2014 May-Jun;24(3):257-65. doi: 10.1111/jon.12008. Epub 2013 Jan 16.
Over the last two decades (123) I-FP-CIT-SPECT, has been used to discriminate neurodegenerative Parkinsonian syndrome from other diseases. BasGan is a freely available software that assists (123) I-FP-CIT-SPECT evaluation by estimating semiquantitative values for each basal nucleus and compares the results to a database of healthy subjects. The aims of this study were: (1) to assess the accuracy of qualitative analysis and of semiquantitative, BasGan-assisted evaluations of (123) I-FP-CIT-SPECT; (2) to compare the accuracy of both methods when applied to "doubtful" cases; (3) to appreciate the reproducibility of the BasGan-assisted evaluations.
Seventy-eight patients were included in this 4-year follow-up study. The diagnostic cut-off for semiquantitative uptake values of each basal nucleus was determined based on ROC curves analysis. Accuracy scores were calculated for the entire population and for "doubtful" cases. Intra- and interoperator reproducibility was assessed.
Accuracy of the software-assisted analyses was high for data from each nucleus. In "doubtful" exams accuracy was higher when using BasGan as opposed to relying solely on visual assessment. Intra- and interoperator reproducibility of the BasGan-assisted evaluations was good to excellent.
BasGan-assisted evaluations of (123) I-FP-CIT-SPECT were very useful, particularly in "doubtful" cases. Multicenter studies are mandatory before routine use of BasGan.
在过去二十年中，123I-FP-CIT单光子发射计算机断层扫描（SPECT）已被用于区分神经退行性帕金森综合征与其他疾病。BasGan是一款免费软件，可通过估计每个基底核的半定量值来辅助123I-FP-CIT SPECT评估，并将结果与健康受试者数据库进行比较。本研究的目的是：（1）评估123I-FP-CIT SPECT定性分析和BasGan辅助半定量评估的准确性；（2）比较两种方法应用于“疑难”病例时的准确性；（3）评估BasGan辅助评估的可重复性。
本4年随访研究纳入了78例患者。根据ROC曲线分析确定每个基底核半定量摄取值的诊断阈值。计算整个人群和“疑难”病例的准确性评分。评估了操作者内和操作者间的可重复性。
软件辅助分析对每个核的数据准确性都很高。在“疑难”检查中，使用BasGan时的准确性高于仅依靠视觉评估。BasGan辅助评估的操作者内和操作者间可重复性良好至优秀。
BasGan辅助的123I-FP-CIT SPECT评估非常有用，尤其是在“疑难”病例中。在常规使用BasGan之前，必须进行多中心研究。
