Bain F T, Merritt A M
Peterson & Smith Equine Hospital, Ocala, FL 32674.
J Am Vet Med Assoc. 1990 Apr 15;196(8):1259-61.
To investigate the possibility that a disorder of potassium balance may have a role in the development of equine rhabdomyolysis, the potassium concentration within erythrocytes (RBC [K+]) and plasma (P [K+]) was measured in 3 groups of horses: group 1, eight 2-year-old fillies that had postexercise muscle soreness within 48 hours of sample collection; group 2, ten 2-year-old fillies subjected to identical management and training conditions (as fillies of group 1) and that did not have signs of myopathy; and group 3, 32 yearlings of both sexes on the farm of origin of groups 1 and 2 that were pastured and not in training. Creatine kinase activity in serum from horses of groups 1 and 2 was also measured. The mean P [K+] was not significantly different between groups, whereas the mean RBC [K+] was significantly (P less than 0.01) lower in group-1 fillies vs group-2 fillies and group-3 horses. Group-1 fillies also had markedly high serum creatine kinase activity. Results of the study revealed significantly lower RBC [K+] in horses that had had signs of myopathy within the preceding 48 hours. This does not prove a causal relationship between RBC potassium depletion and myopathy, but does suggest that decreased RBC [K+] may be observed in horses with exercise-related myopathy.
为了研究钾平衡紊乱是否可能在马横纹肌溶解症的发生中起作用，对三组马的红细胞（RBC [K+]）和血浆（P [K+]）中的钾浓度进行了测量：第1组，八匹2岁的小母马，在采集样本后48小时内出现运动后肌肉酸痛；第2组，十匹2岁的小母马，接受与第1组小母马相同的管理和训练条件，且没有肌病迹象；第3组，32匹一岁马，来自第1组和第2组马匹的原养殖场，在牧场放牧，未进行训练。还测量了第1组和第2组马匹血清中的肌酸激酶活性。各组之间的平均P [K+]没有显著差异，而第1组小母马的平均RBC [K+]显著低于（P<0.01）第2组小母马和第3组马匹。第1组小母马的血清肌酸激酶活性也明显较高。研究结果显示，在之前48小时内有肌病迹象的马匹中，RBC [K+]显著降低。这并不能证明红细胞钾耗竭与肌病之间存在因果关系，但确实表明，与运动相关的肌病马匹可能会出现RBC [K+]降低的情况。
