Beech J, Lindborg S, Braund K G
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, New Bolton Center, Kennett Square.
Res Vet Sci. 1993 Jul;55(1):43-51. doi: 10.1016/0034-5288(93)90032-b.
Potassium concentrations were measured in semimembranosus muscle, plasma and erythrocytes, and the urinary fractional excretion determined in normal horses and those that had chronic intermittent exercise-associated rhabdomyolysis. Muscle from the rhabdomyolysis horses was also evaluated microscopically. The horses with rhabdomyolysis had a lower muscle potassium concentration on a dry weight basis. Although the wet weight potassium content was also lower, the difference was not significant. Urinary fractional excretion of potassium (and also sodium and chloride) did not differ significantly between the two groups although the rhabdomyolysis group had a lower percentage excretion of potassium. Erythrocyte potassium concentration was similar for both groups. Low grade to moderate degenerative myopathy or absence of lesions was seen on microscopic sections of muscle from horses with rhabdomyolysis; only one had a vacuolar myopathy and potassium content was not determined. These results suggest that altered muscle potassium content may be a factor in rhabdomyolysis.
测定了正常马匹以及患有慢性间歇性运动相关性横纹肌溶解症马匹的半膜肌、血浆和红细胞中的钾浓度，并测定了尿中钾的排泄分数。还对横纹肌溶解症马匹的肌肉进行了显微镜评估。横纹肌溶解症马匹的肌肉在干重基础上钾浓度较低。虽然湿重钾含量也较低，但差异不显著。两组之间钾（以及钠和氯）的尿排泄分数没有显著差异，尽管横纹肌溶解症组的钾排泄百分比较低。两组的红细胞钾浓度相似。横纹肌溶解症马匹的肌肉显微镜切片显示有轻度至中度退行性肌病或无病变；只有一匹马患有空泡性肌病，未测定其钾含量。这些结果表明，肌肉钾含量的改变可能是横纹肌溶解症的一个因素。
